利用w-shingling将相似基因分组到元桶中

Jorge Cedeno-Femández, F. Torres-Rojas
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引用次数: 0

摘要

铜绿假单胞菌(Pseudomonas aeruginosa AGI)是一种机会性超级细菌,可感染因眼、耳、烧伤等感染性疾病或囊性纤维化等慢性疾病导致免疫系统减弱的患者。这种细菌的基因没有信息,有必要确定它们的功能,以便寻求治疗,帮助受感染的病人。使用w-shingling,生成元桶,根据相似性对基因进行分组。每个元桶都包含有或没有信息的基因,后者可以与它们所拥有的信息相关联。此外,本文还进行了一个析因实验,将该算法应用于从公共数据库中获得的一组基因,其中分组在元桶中的基因的平均相似性达到98%。
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Using w-shingling to Group Similar Genes intoMetabuckets
Abstract-The Pseudomonas aeruginosa AGI is an opportunistic superbug that affects patients with weakened immune systems due to infectious diseases in eyes, ears, burns or chronic diseases such as cystic flbrosis. This bacterium has genes without information and it is necessary to determine the function they fulfill in order to seek medical treatment that helps infected patients. Using w-shingling, metabuckets are generated that group genes by their similarity. Each metabucket contains genes with or without information, the latter can be associated with information about what they do possess. In addition, a factorial experiment is presented with the results of applying the algorithm to a set of genes obtained from public databases, where the average similarity of the genes grouped in metabuckets reaches 98%.
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