过敏性疾病

Great Ormond Street Handbook of Paediatrics Pub Date : 2019-08-08 DOI:10.1201/b19495-23

Adam Fox, George Du Toit, Stephan Strobel

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引用次数: 0

摘要

1.4对室内尘螨(HDM)过敏，这是一种常见的空气过敏原，在全世界85%的哮喘患者中观察到。HDM是一种复杂的免疫抗原，可激活先天性和适应性免疫反应(1)。此外，据报道，HDM中的蛋白酶，如胰蛋白酶样酶，可促进对蛋白质的致敏性，从而导致过敏反应(2)。为了促进过敏性哮喘研究，Chondrex公司提供了HDM提取物作为临床相关的过敏原，用于诱导小鼠哮喘模型，该模型模拟了哮喘患者如何被空气过敏原致敏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Allergic Diseases

1.4 Allergies against house dust mites (HDM), a common aeroallergen, are observed in up to 85% of asthmatic patients worldwide. HDM is an immunologically complex antigen which activates both innate and adaptive immune responses (1). Moreover it was reported that proteinases, such as trypsin-like enzymes, in HDM promoted allergenicity to proteins, resulting in allergic reactions (2). To facilitate allergic asthma research, Chondrex, Inc. provides HDM extract as a clinically relevant allergen for the induction of a mouse asthma model that mimics how asthmatic patients are sensitized with aeroallergens.

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