肿瘤/免疫系统细胞相互作用的动力学模型

L. Arlotti, A. Gamba, M. Lachowicz
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引用次数: 40

摘要

本文提出了一个与免疫系统竞争的细胞肿瘤动力学模型。该现象的特征尺度为细胞尺度,模型是用类似于动力学理论的概率方法建立的。相互作用的个体是参与肿瘤和免疫系统之间竞争的群体中的细胞。相互作用可以改变肿瘤的激活状态,引起肿瘤的增殖或破坏。该模型用双线性的积分-微分方程组表示。对该模型进行了初步的数学分析和计算仿真。
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A Kinetic Model of Tumor/Immune System Cellular Interactions
In this paper, a model of cellular tumor dynamics in competition with the immune system is proposed. The characteristic scale of the phenomenon is the cellular one and the model is developed with probabilistic methods analogous to those of the kinetic theory. The interacting individuals are the cells of the populations involved in the competition between the tumor and the immune system. Interactions can change the activation state of the tumor and cause tumor proliferation or destruction. The model is expressed in terms of a bi-linear system of integro-differential equations. Some preliminary mathematical analysis of the model as well as computational simulations are presented.
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