{"title":"肿瘤/免疫系统细胞相互作用的动力学模型","authors":"L. Arlotti, A. Gamba, M. Lachowicz","doi":"10.1080/10273660290015170","DOIUrl":null,"url":null,"abstract":"In this paper, a model of cellular tumor dynamics in competition with the immune system is proposed. The characteristic scale of the phenomenon is the cellular one and the model is developed with probabilistic methods analogous to those of the kinetic theory. The interacting individuals are the cells of the populations involved in the competition between the tumor and the immune system. Interactions can change the activation state of the tumor and cause tumor proliferation or destruction. The model is expressed in terms of a bi-linear system of integro-differential equations. Some preliminary mathematical analysis of the model as well as computational simulations are presented.","PeriodicalId":294267,"journal":{"name":"Journal of Theoretical Medicine","volume":"34 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"40","resultStr":"{\"title\":\"A Kinetic Model of Tumor/Immune System Cellular Interactions\",\"authors\":\"L. Arlotti, A. Gamba, M. Lachowicz\",\"doi\":\"10.1080/10273660290015170\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this paper, a model of cellular tumor dynamics in competition with the immune system is proposed. The characteristic scale of the phenomenon is the cellular one and the model is developed with probabilistic methods analogous to those of the kinetic theory. The interacting individuals are the cells of the populations involved in the competition between the tumor and the immune system. Interactions can change the activation state of the tumor and cause tumor proliferation or destruction. The model is expressed in terms of a bi-linear system of integro-differential equations. Some preliminary mathematical analysis of the model as well as computational simulations are presented.\",\"PeriodicalId\":294267,\"journal\":{\"name\":\"Journal of Theoretical Medicine\",\"volume\":\"34 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"40\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Theoretical Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/10273660290015170\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Theoretical Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/10273660290015170","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A Kinetic Model of Tumor/Immune System Cellular Interactions
In this paper, a model of cellular tumor dynamics in competition with the immune system is proposed. The characteristic scale of the phenomenon is the cellular one and the model is developed with probabilistic methods analogous to those of the kinetic theory. The interacting individuals are the cells of the populations involved in the competition between the tumor and the immune system. Interactions can change the activation state of the tumor and cause tumor proliferation or destruction. The model is expressed in terms of a bi-linear system of integro-differential equations. Some preliminary mathematical analysis of the model as well as computational simulations are presented.