NuMA1通过抑制内吞作用促进轴突初始片段组装

The Journal of Cell Biology Pub Date : 2019-11-14 DOI:10.1083/jcb.201907048

Tomohiro Torii, Y. Ogawa, Cheng-Hsin Liu, T. Ho, Hamdan Hamdan, Chih-Chuan Wang, J. Oses-Prieto, A. Burlingame, M. Rasband

{"title":"NuMA1通过抑制内吞作用促进轴突初始片段组装","authors":"Tomohiro Torii, Y. Ogawa, Cheng-Hsin Liu, T. Ho, Hamdan Hamdan, Chih-Chuan Wang, J. Oses-Prieto, A. Burlingame, M. Rasband","doi":"10.1083/jcb.201907048","DOIUrl":null,"url":null,"abstract":"Axon initial segments (AISs) initiate action potentials and regulate the trafficking of vesicles between somatodendritic and axonal compartments. Torii et al. show that NuMA1 is transiently located at the AIS and promotes rapid AIS assembly by inhibiting the endocytosis of neurofascin-186.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"20","resultStr":"{\"title\":\"NuMA1 promotes axon initial segment assembly through inhibition of endocytosis\",\"authors\":\"Tomohiro Torii, Y. Ogawa, Cheng-Hsin Liu, T. Ho, Hamdan Hamdan, Chih-Chuan Wang, J. Oses-Prieto, A. Burlingame, M. Rasband\",\"doi\":\"10.1083/jcb.201907048\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Axon initial segments (AISs) initiate action potentials and regulate the trafficking of vesicles between somatodendritic and axonal compartments. Torii et al. show that NuMA1 is transiently located at the AIS and promotes rapid AIS assembly by inhibiting the endocytosis of neurofascin-186.\",\"PeriodicalId\":343306,\"journal\":{\"name\":\"The Journal of Cell Biology\",\"volume\":\"5 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"20\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Cell Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1083/jcb.201907048\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1083/jcb.201907048","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 20

摘要

轴突初始段(AISs)启动动作电位并调节体树突和轴突间囊泡的运输。Torii等人的研究表明，NuMA1短暂地位于AIS，并通过抑制神经束蛋白的内吞作用来促进AIS的快速组装。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

NuMA1 promotes axon initial segment assembly through inhibition of endocytosis

Axon initial segments (AISs) initiate action potentials and regulate the trafficking of vesicles between somatodendritic and axonal compartments. Torii et al. show that NuMA1 is transiently located at the AIS and promotes rapid AIS assembly by inhibiting the endocytosis of neurofascin-186.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

The Journal of Cell Biology

自引率

0.00%

发文量