Simulation of paced excitation in a large scale realistic ventricular model

Simulations of paced ventricular excitation using a model based on Beeler/Reuter ion dynamics have been performed. The resulting activation sequence is compared to one computed from ECG's measured on a patient undergoing cardiac pacing at the same stimulus location. Results show that in spite of the isotropic, homogeneous structure of the model major characteristics of the activation sequences are similar. In addition, ECG waveforms in the extremity leads computed from the simulated seqlience are similar to the ones measured on the patient.