Pub Date : 1993-12-16DOI: 10.1109/IEMBS.1993.979095
E. Goodall, L. M. Kosterman, J. Struijk, J. Holsheimer
Computer simulations were perfonned to investigate the influence of stimulus amplitude on cathodal activation delay, propagation delay and blocking during stimulation with a bipolar cuff electrode. Activation and propagation delays were combined in a total delay term which was minimized between the excitation and blocking thresholds.
{"title":"Simulation of activation and propagation delay during tripolar neural stimulation","authors":"E. Goodall, L. M. Kosterman, J. Struijk, J. Holsheimer","doi":"10.1109/IEMBS.1993.979095","DOIUrl":"https://doi.org/10.1109/IEMBS.1993.979095","url":null,"abstract":"Computer simulations were perfonned to investigate the influence of stimulus amplitude on cathodal activation delay, propagation delay and blocking during stimulation with a bipolar cuff electrode. Activation and propagation delays were combined in a total delay term which was minimized between the excitation and blocking thresholds.","PeriodicalId":408657,"journal":{"name":"Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ","volume":"188 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124154931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-12-16DOI: 10.1109/IEMBS.1993.979093
R. Hoekema, J. Struijk, C. Venner, E. Goodall, J. Holsheimer
This paper deals with the first step in the modeling of newe stimulation: the calculation of the potential field in a 3D volume conductor model of the nerve. surroundings and electrodes. Because of its time efficiency, a multigrid method was used to calculate the field. Compared to a Gauss-Seidel relaxation (overrelaxation factor = 1.7), a calculation time reduction of a factor 20 was obtained
{"title":"Calculation of the potential field in nerve stimulation using a multigrid method","authors":"R. Hoekema, J. Struijk, C. Venner, E. Goodall, J. Holsheimer","doi":"10.1109/IEMBS.1993.979093","DOIUrl":"https://doi.org/10.1109/IEMBS.1993.979093","url":null,"abstract":"This paper deals with the first step in the modeling of newe stimulation: the calculation of the potential field in a 3D volume conductor model of the nerve. surroundings and electrodes. Because of its time efficiency, a multigrid method was used to calculate the field. Compared to a Gauss-Seidel relaxation (overrelaxation factor = 1.7), a calculation time reduction of a factor 20 was obtained","PeriodicalId":408657,"journal":{"name":"Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130508792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-12-16DOI: 10.1109/IEMBS.1993.979094
J. Hoisheimer, N. Tas, J. He, J. A. den Boer, J. Struijk, R. Hokema, G. Barolat, A.R. Romeboom
{"title":"Relationship between perception threshold and thickness of the dorsal CSF-layer in epidural spinal cord stimulation","authors":"J. Hoisheimer, N. Tas, J. He, J. A. den Boer, J. Struijk, R. Hokema, G. Barolat, A.R. Romeboom","doi":"10.1109/IEMBS.1993.979094","DOIUrl":"https://doi.org/10.1109/IEMBS.1993.979094","url":null,"abstract":"","PeriodicalId":408657,"journal":{"name":"Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114875715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-12-01DOI: 10.1109/IEMBS.1993.979316
H. Itoh, N. Makimura, T. Arai, H. Tsubamoto, K. Furuya, M. Kikuchi, I. Nagata
We tnvestlgated the Influence of l lght envlronment on the development of mouse egg in virro. The 1-cell mouse eggs were irradlated by varlous laser l ights of whlch wavelengths were 632.8nm, 543nm, and 442nm in vitro. Actual llght environment by means of the microscope IIght source In IVFET ( in vitro fertlllzatlon-embryo transfer) was measured to set the I lght dose In th is experlment. Mouse eggs were cultured to observe cellular development stage. In case of 632.8nm radiation of 500kJ/m2 I n dose ( 2 0 t lmes larger than actual l lght envlronment), 97% of eggs stopped their division. In the case of 543nm and 442nm radiations no influences were observed In egg division. These results suggested that l lght environment migh t af fect o n the development of mouse egg in vitro.
{"title":"Influence of light irradiation an the development of mouse eggs in culture","authors":"H. Itoh, N. Makimura, T. Arai, H. Tsubamoto, K. Furuya, M. Kikuchi, I. Nagata","doi":"10.1109/IEMBS.1993.979316","DOIUrl":"https://doi.org/10.1109/IEMBS.1993.979316","url":null,"abstract":"We tnvestlgated the Influence of l lght envlronment on the development of mouse egg in virro. The 1-cell mouse eggs were irradlated by varlous laser l ights of whlch wavelengths were 632.8nm, 543nm, and 442nm in vitro. Actual llght environment by means of the microscope IIght source In IVFET ( in vitro fertlllzatlon-embryo transfer) was measured to set the I lght dose In th is experlment. Mouse eggs were cultured to observe cellular development stage. In case of 632.8nm radiation of 500kJ/m2 I n dose ( 2 0 t lmes larger than actual l lght envlronment), 97% of eggs stopped their division. In the case of 543nm and 442nm radiations no influences were observed In egg division. These results suggested that l lght environment migh t af fect o n the development of mouse egg in vitro.","PeriodicalId":408657,"journal":{"name":"Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123063061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-12-01DOI: 10.1109/IEMBS.1993.978494
M. Grinstaff, N. Desai, K. Kolbeck, R. Magin, K. Suslick, A. Webb, L. Wilmes, M. Wong
MRI contrast agents have been widely used to enhance tumor detection and improve tumor image quality. Particulate MRI contrast agents using conventional proton magnetic resonance imaging have met with limited success. Herein, we report a process to microencapsulate fluorinated hydrocarbons in a biocompatible protein shell and their efficacy as contrast agents for fluorine magnetic resonance imaging (^(19)F MRI).
{"title":"Fluorinated hydrocarbons as MRI contrast agents","authors":"M. Grinstaff, N. Desai, K. Kolbeck, R. Magin, K. Suslick, A. Webb, L. Wilmes, M. Wong","doi":"10.1109/IEMBS.1993.978494","DOIUrl":"https://doi.org/10.1109/IEMBS.1993.978494","url":null,"abstract":"MRI contrast agents have been widely used to enhance tumor \u0000detection and improve tumor image quality. Particulate MRI contrast agents using conventional proton magnetic resonance imaging have met with limited success. Herein, we report a process to microencapsulate fluorinated hydrocarbons in a biocompatible protein shell and their efficacy as contrast agents for fluorine magnetic resonance imaging (^(19)F MRI).","PeriodicalId":408657,"journal":{"name":"Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ","volume":" 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120829727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-12-01DOI: 10.1109/IEMBS.1993.979307
T. Arai, K. Mizuno, M. Kikuchi, M. Sakurada, A. Miyamoto, A. Kurita, H. Nakarnura, A. Utsumi, M. Katoh, K. Takeuchi
A new laser coronary angloplasty system using CO laser and a manipulatable angloscope was described. CO laser was employed as therapy laser due t o its strong vaporization capabi l i ty and f lex ib le f iber dellvery characteristics. The medical CO laser equipment wh ich emi t ted 5um in w a v e l e n g t h w a s d e v e l o p e d . The manipulatable angioscope catheter of which dlmenslons were 1.8 m m In dlameter and 0.9 m in length realized precise targeting of laser irradlation and intraluminal diagnosis. The cont ro l sys tem prevented fa i lu re laser irradiation, and fiber thermal destructlon.
介绍了一种新型的激光冠状动脉成形术系统，该系统由CO激光和可操作的血管镜组成。一氧化碳激光器因其汽化能力强、传输光纤灵活等特点而被用作治疗激光。医用CO激光设备的波长可达5um，是一种新型的医用CO激光设备。直径为1.8 m m，长度为0.9 m的可操作血管镜导管实现了激光照射和腔内诊断的精确定位。该控制系统防止了激光辐照和光纤热破坏。
{"title":"New laser coronary angioplasty system using manipulatable angioscope and co laser with infrared glass fiber","authors":"T. Arai, K. Mizuno, M. Kikuchi, M. Sakurada, A. Miyamoto, A. Kurita, H. Nakarnura, A. Utsumi, M. Katoh, K. Takeuchi","doi":"10.1109/IEMBS.1993.979307","DOIUrl":"https://doi.org/10.1109/IEMBS.1993.979307","url":null,"abstract":"A new laser coronary angloplasty system using CO laser and a manipulatable angloscope was described. CO laser was employed as therapy laser due t o its strong vaporization capabi l i ty and f lex ib le f iber dellvery characteristics. The medical CO laser equipment wh ich emi t ted 5um in w a v e l e n g t h w a s d e v e l o p e d . The manipulatable angioscope catheter of which dlmenslons were 1.8 m m In dlameter and 0.9 m in length realized precise targeting of laser irradlation and intraluminal diagnosis. The cont ro l sys tem prevented fa i lu re laser irradiation, and fiber thermal destructlon.","PeriodicalId":408657,"journal":{"name":"Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124651444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-12-01DOI: 10.1109/IEMBS.1993.978504
K. Soetanto, S.H. Wang, T. Sugimoto, M. Okujima
Measuring tissue properties in-vivo is highly desirable to obviate concerns for changes of tissue properties following blood stains and coagulation, autolysis, temperawe change, or fixation. Characterization of surgically exposed tissues by ultrasound is an extremely important research area. A close correlation between tissue pathology and acoustic parameters, including sound speed, attenuation and backscatter coefficients and Uieir frequency dependencies would significantly enhance ultxasonic tissue characterization research and would be valuable for quantitative interpretation of diagnostic ultrasound images. Physicians could be assisted in diagnosis, treatment planning, and following progression and regression of diseases. We proposed a novel design for PVDF transducers in which ultrasound transducers are fabricated at the tips of calipers (analog and digital) as miniprobe. Measurement techniques for this purpose are suggested. Feasibility of this miniprobe has been verified using measurement of phantoms and mammalian tissues.
{"title":"A measurement technique of surgically exposed tissue by ultrasound","authors":"K. Soetanto, S.H. Wang, T. Sugimoto, M. Okujima","doi":"10.1109/IEMBS.1993.978504","DOIUrl":"https://doi.org/10.1109/IEMBS.1993.978504","url":null,"abstract":"Measuring tissue properties in-vivo is highly desirable to obviate concerns for changes of tissue properties following blood stains and coagulation, autolysis, temperawe change, or fixation. Characterization of surgically exposed tissues by ultrasound is an extremely important research area. A close correlation between tissue pathology and acoustic parameters, including sound speed, attenuation and backscatter coefficients and Uieir frequency dependencies would significantly enhance ultxasonic tissue characterization research and would be valuable for quantitative interpretation of diagnostic ultrasound images. Physicians could be assisted in diagnosis, treatment planning, and following progression and regression of diseases. We proposed a novel design for PVDF transducers in which ultrasound transducers are fabricated at the tips of calipers (analog and digital) as miniprobe. Measurement techniques for this purpose are suggested. Feasibility of this miniprobe has been verified using measurement of phantoms and mammalian tissues.","PeriodicalId":408657,"journal":{"name":"Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128525700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-12-01DOI: 10.1109/IEMBS.1993.978652
J. Goyette, G. Lapin, M. Kang, A. Katsaggelos
In this paper the point spread function of autoradiography is experimentally measured and used with digital image restoration techniques to improve the resolution of autoradiographs. We compare two regularized iterative image restoration algorithms applied to autoradiography. A nonlinear filter is used for the removal of f i l m grain noise prior to restoration. Our results indicate a 23% improvement in resolution.
{"title":"Regularized iterative image restoration algorithms applied to autoradiography","authors":"J. Goyette, G. Lapin, M. Kang, A. Katsaggelos","doi":"10.1109/IEMBS.1993.978652","DOIUrl":"https://doi.org/10.1109/IEMBS.1993.978652","url":null,"abstract":"In this paper the point spread function of autoradiography is experimentally measured and used with digital image restoration techniques to improve the resolution of autoradiographs. We compare two regularized iterative image restoration algorithms applied to autoradiography. A nonlinear filter is used for the removal of f i l m grain noise prior to restoration. Our results indicate a 23% improvement in resolution.","PeriodicalId":408657,"journal":{"name":"Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133662214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-12-01DOI: 10.1109/IEMBS.1993.979000
D. J. Foran, D. Winkelmann, R. Trelstad
{"title":"Medical imaging over a network of heterogenous X-servers","authors":"D. J. Foran, D. Winkelmann, R. Trelstad","doi":"10.1109/IEMBS.1993.979000","DOIUrl":"https://doi.org/10.1109/IEMBS.1993.979000","url":null,"abstract":"","PeriodicalId":408657,"journal":{"name":"Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ","volume":"264 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132436772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-12-01DOI: 10.1109/IEMBS.1993.978530
Cheng Yi, E. Micheli-Tzanakou, D. Shindler, J. Kostis
Ultrasonic myocardial echocardiogram is a promising approach to diagnosing myocardial infarctioni'l. We digitize echocardiographic images to study ultrasound backscatter for scar tissue detection. Neural network analysis is a successful approach to scar detection121. We improve the structure of multi-layer perceptton combined with the feedback optimization algorithm ALOPEX to make it more general and we also introduce the noisy train-
{"title":"Study of echocardiogram for myocardial infarction using neural networks","authors":"Cheng Yi, E. Micheli-Tzanakou, D. Shindler, J. Kostis","doi":"10.1109/IEMBS.1993.978530","DOIUrl":"https://doi.org/10.1109/IEMBS.1993.978530","url":null,"abstract":"Ultrasonic myocardial echocardiogram is a promising approach to diagnosing myocardial infarctioni'l. We digitize echocardiographic images to study ultrasound backscatter for scar tissue detection. Neural network analysis is a successful approach to scar detection121. We improve the structure of multi-layer perceptton combined with the feedback optimization algorithm ALOPEX to make it more general and we also introduce the noisy train-","PeriodicalId":408657,"journal":{"name":"Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132584526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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