L. Smirnova, E. Epimakhova, D. Kazantseva, D. Kamaeva, A. Semke, S. Ivanova
{"title":"精神分裂症患者血清氧化还原酶活性对细胞凋亡水平的影响","authors":"L. Smirnova, E. Epimakhova, D. Kazantseva, D. Kamaeva, A. Semke, S. Ivanova","doi":"10.33920/med-01-2303-07","DOIUrl":null,"url":null,"abstract":"This paper presents the results of a study of the effect of IgG with catalase and superoxide dismutase activities, isolated from the blood serum of patients with paranoid schizophrenia, on the parameters of apoptotic cell death in an in vitro experiment, using a model of the SH-SY5Y human neuroblastoma cell line. The catalase and superoxide dismutase activities of immunoglobulins G were evaluated, and these activities were proved to belong to antibodies. It has been shown for the first time that abzymes from patients with schizophrenia in the therapeutic remission phase significantly reduce the level of apoptosis in the SH-SY5Y human neuroblastoma cell line after 24 incubations in an in vitro experiment.","PeriodicalId":447580,"journal":{"name":"Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In vitro effect of serum IgGs with oxidoreductase activities of schizophrenic patients on apoptosis level\",\"authors\":\"L. Smirnova, E. Epimakhova, D. Kazantseva, D. Kamaeva, A. Semke, S. Ivanova\",\"doi\":\"10.33920/med-01-2303-07\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This paper presents the results of a study of the effect of IgG with catalase and superoxide dismutase activities, isolated from the blood serum of patients with paranoid schizophrenia, on the parameters of apoptotic cell death in an in vitro experiment, using a model of the SH-SY5Y human neuroblastoma cell line. The catalase and superoxide dismutase activities of immunoglobulins G were evaluated, and these activities were proved to belong to antibodies. It has been shown for the first time that abzymes from patients with schizophrenia in the therapeutic remission phase significantly reduce the level of apoptosis in the SH-SY5Y human neuroblastoma cell line after 24 incubations in an in vitro experiment.\",\"PeriodicalId\":447580,\"journal\":{\"name\":\"Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-03-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33920/med-01-2303-07\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33920/med-01-2303-07","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In vitro effect of serum IgGs with oxidoreductase activities of schizophrenic patients on apoptosis level
This paper presents the results of a study of the effect of IgG with catalase and superoxide dismutase activities, isolated from the blood serum of patients with paranoid schizophrenia, on the parameters of apoptotic cell death in an in vitro experiment, using a model of the SH-SY5Y human neuroblastoma cell line. The catalase and superoxide dismutase activities of immunoglobulins G were evaluated, and these activities were proved to belong to antibodies. It has been shown for the first time that abzymes from patients with schizophrenia in the therapeutic remission phase significantly reduce the level of apoptosis in the SH-SY5Y human neuroblastoma cell line after 24 incubations in an in vitro experiment.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
