Lenvatinib在三级肿瘤医院间变性甲状腺癌(ATC)中的应用-一个研究所的经验

R. Sharma, P. Dattatreya, A. Suresh, C. Vamsy
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摘要

间变性甲状腺癌(ATC)是一种侵袭性的罕见癌症,治疗选择有限,生存期短。鉴于最初的病例报告显示lenvatinib有良好的临床反应,我们在我们的研究所使用了相同的药物。我们将在2018-2021年期间对4例病例进行回顾性分析。结果非常乐观,75%的患者显示出有临床意义的肿瘤消退。高血压是最常见的副作用,应积极管理。我们认为lenvatinib仍然是一种安全有效的治疗顽固性间变性甲状腺癌的方法。
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Lenvatinib in Anaplastic Thyroid Carcinoma (ATC) in a Tertiary Caner Hospital- a Single Institute Experience
Anaplastic Thyroid Carcinoma (ATC) is an aggressive rare form of caner with limited treatment options and short survival. In view of initial case reports have shown some good clinical response with lenvatinib, we used the same in our institute. We are presenting a retrospective series of 4 cases between 2018-2021. It showed very promising results with 75% showing clinically meaningful regression of tumor. Hypertension is the most common side effect, which should be aggressively managed. We feel that, lenvatinib remains a safe and effective option to explore in patients with refractory anaplastic thyroid carcinoma.
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