Nootan Pandey, Daniel Keifenheim, M. Yoshida, Victoria A Hassebroek, Caitlin Soroka, Y. Azuma, D. J. Clarke
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Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases
To prevent chromosome missegregation, a metaphase checkpoint is activated when topoisomerase II is catalytically inhibited and DNA catenations persist. Pandey et al. dissect the key molecular events triggering this regulatory system.
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