Physical Modelling of Large-Area Single-Molecule Organic Transistors

Single-Molecule organic transistors embedding a large-area bioreceptor surface can potentially revolutionize the current medical diagnostic approaches. For instance, sensing a single molecule in a biological fluid can provide early and noninvasive detection of a disease. The development of a reliable and multiplexed electronic large-area single-molecule technology urgently requires the improvement of our current understanding. Here we propose a physical model of large-area single-molecule organic transistor sensors. The model describes the electrical measurements and provides meaningful information about the sensor operation. The bioelectronic responses can be linked to the physical parameters and guidelines for device optimization are suggested.