机械敏感钙闪烁促进紧密连接重塑过程中RhoA的持续激活

The Journal of Cell Biology Pub Date : 2022-03-07 DOI:10.1083/jcb.202105107

Saranyaraajan Varadarajan, Shahana A Chumki, Rachel E. Stephenson, Eileen Misterovich, Jessica L. Wu, Claire E Dudley, I. Erofeev, A. Goryachev, Ann L. Miller

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引用次数: 21

摘要

Varadarajan等人发现钙闪光调节上皮屏障功能。通过实时成像、光遗传学和激光诱导的紧密连接损伤，他们发现机械敏感通道依赖性钙闪烁促进RhoA的持续局部激活，使细胞能够修复由机械刺激引起的紧密连接泄漏。

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Mechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling

Varadarajan et al. find that calcium flashes regulate epithelial barrier function. Using live imaging, optogenetics, and laser-induced tight junction injury, they show that mechanosensitive channel-dependent calcium flashes promote sustained local activation of RhoA, allowing cells to repair tight junction leaks induced by mechanical stimuli.

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The Journal of Cell Biology

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