脂质门控TRPC3通道需要定位在STIM1定义的ER/PM连接处

The Journal of Cell Biology Pub Date : 2022-04-13 DOI:10.1083/jcb.202107120

Haiping Liu, Wei Lin, Spencer R Leibow, Alexander J Morateck, Malini Ahuja, S. Muallem

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引用次数: 11

摘要

PI(4,5)P2是ER/PM连接处的关键脂质，在调节TRPC通道中具有多种作用，包括将通道招募到连接处以促进受体刺激激活、通道开孔和通道离子选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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TRPC3 channel gating by lipids requires localization at the ER/PM junctions defined by STIM1

PI(4,5)P2, a key lipid at ER/PM junctions, has multiple roles in regulating TRPC channels, which includes recruitment of the channel to the junctions to facilitate activation by receptor stimulation, channel pore opening, and channel ionic selectivity.

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The Journal of Cell Biology

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