苏铁目裸子植物的生物活性研究

W. Negm, K. A. El-Seoud, A. Kabbash, Mona El-Aasr
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引用次数: 7

摘要

众所周知,人们利用植物来治疗许多疾病。苏铁属植物是一种含有多种活性成分的古老植物。由于对Cycadales缺乏足够的研究,我们进行了这项研究。本研究调查并比较了四种不同植物的不同生物活性。本文首次测定了苏铁、苏铁、刺桐和laurentius的细胞毒、抗氧化和抗菌活性。Dioon spinlosum对VERO细胞株的细胞毒活性显著高于5-氟尿嘧啶。棘木清除自由基的能力最强,其次是苏铁。棘豆对DNA损伤的保护活性最高,高于阳性对照。棘棘的抗溶血抗氧化活性最高,其次是laurentianus。其中棘球菊的抑菌活性最高。大多数苏铁属植物,尤其是刺草,显示出显著的生物活性,对未来的药物开发有很大的前景。
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Biological Activity Investigation of Some Gymnosperm Plants Belong to Cycadales Order
People are known to utilize plants for treatment of many diseases. Cycadales are one of these ancient plants that contained different active constituents. Due to the lack of adequate research on Cycadales, we conducted this study. The current study investigated and compared different biological activities for four different plants. Cycas thouarsii, Cycas pectinata, Dioon spinulosum and Encephalartos laurentianus were tested for the first time for cytotoxic, antioxidant and antimicrobial activities. Dioon spinulosum displayed significant cytotoxic activity on VERO cell line that was higher than 5-Fluorouracil. D. spinulosum possessed the highest radical scavenging activity followed by Cycas thouarsii. D. spinulosum showed the highest protective activity against DNA damage which was higher than the positive control. D. spinulosum showed the highest antihemolytic antioxidant activity followed by Encephalartos laurentianus. D. spinulosum presented the highest antimicrobial activity among the tested plants. Most Cycadales tested plants especially D. spinulosum displayed significant biological activities that are promising for future drug discovery.
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