CLASP2结合到弯曲的微管尖端促进通量和稳定着丝点附着

The Journal of Cell Biology Pub Date : 2019-11-22 DOI:10.1083/jcb.201905080

Hugo Girão, Naoyuki Okada, T. Rodrigues, Alexandra Silva, A. C. Figueiredo, Z. García, Tatiana Moutinho‐Santos, I. Hayashi, Jorge E Azevedo, Sandra Macedo-Ribeiro, H. Maiato

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引用次数: 23

摘要

gir等人利用CLASP2的结构导向功能突变体表明，通过eb -蛋白相互作用识别生长的微管正端，以及通过TOG2和TOG3结构域与弯曲的微管原丝结合的能力，促进了极向通量所需的着丝微管的生长和稳定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments

Girão et al. use structure-guided functional mutants of CLASP2 to show that recognition of growing microtubule plus-ends through EB–protein interaction and the ability to associate with curved microtubule protofilaments through TOG2 and TOG3 domains promote growth and stabilization of kinetochore–microtubules required for poleward flux.

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The Journal of Cell Biology

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