基因选择的网络传播模型

Wei Zhang, Baryun Hwang, Baolin Wu, R. Kuang
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引用次数: 2

摘要

在本文中,我们探索了几种从微阵列基因表达数据集中进行基因选择的网络传播方法。网络传播方法通过统一的机器学习框架捕获基因共表达和差异表达。在5个乳腺癌数据集上进行的大规模实验证实,与现有方法相比,网络传播方法能够选择更具生物学可解释性和跨多个数据集更具一致性的基因。
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Network propagation models for gene selection
In this paper, we explore several network propagation methods for gene selection from microarray gene expression datasets. The network propagation methods capture gene co-expression and differential expression with unified machine learning frameworks. Large scale experiments on five breast cancer datasets validated that the network propagation methods are capable of selecting genes that are more biologically interpretable and more consistent across multiple datasets, compared with the existing approaches.
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