芯片上的基础测序使用两阶段的反应控制方案:3.6倍的速度和1/100减少数据量基于isfet的DNA测序仪

2013 IEEE Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2013-12-12 DOI:10.1109/BioCAS.2013.6679668

Y. Yanagawa, N. Itabashi, S. Migitaka, Takahide Yokoi, Makiko Yoshida, T. Kawahara

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引用次数: 4

摘要

为了减少离子敏感场效应管(ISFET) DNA测序仪的数据量和分析时间，提出了一种具有背景抵消电路的新型两级反应控制方案。该方案成功地降低了背景噪声，避免了耗时的背景分析。它还将样本到数据的时间缩短了72%(快了3.6倍)，数据量减少了两个数量级。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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On-chip base sequencing using a two-stage reaction-control scheme: 3.6-times-faster and 1/100-reduced-data-volume ISFET-based DNA sequencer

A novel two-stage reaction-control scheme with a background-cancelling circuit - for reducing data volume and analysis time of an ion-sensitive-FET (ISFET) - based DNA sequencer-is proposed. The scheme successfully reduces the background noise and renders time-consuming background analysis unnecessary. It also reduces sample-to-data time by 72% (3.6 times faster) and data volume by two orders of magnitude.

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2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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