On the question of carcinogenesis in superinvasive opisthorchiasis

Retrospective analysis of foreign literature present in PubMed was carried out with the purpose to define possible influence of superinvasive opisthorchiasis on possible development of cholangiocellular carcinoma. After the research we conclude that O. Felineus doesn’t have an entry point during the initiation stage of carcinogenesis but rather acts as a promotor of cholangiocarcinoma (СС), and therefore cannot be considered a primary cause of the disease without additional influence of another carcinogens and specific factors that increase the probability of cholangiocarcinoma development (chronic inflammation, free radicals). Keywords: superinvasive opisthorchiasis, parasitism, immune system, carcinogenesis.