一级神经认知筛选试验及其应用

F. Salis
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引用次数: 0

摘要

寻找一种能够减缓神经认知障碍(NCD)进展的有效疗法是生物医学研究的一个雄心勃勃的目标。2021年6月,美国食品和药物管理局批准Aducanumab用于治疗阿尔茨海默病——全球最常见的痴呆症病因[1]。该药物是一种单克隆抗体,可导致脑内淀粉样蛋白-β斑块减少[2]。无论其有效性是否得到证实,事实仍然是,将从任何治疗中获益最多的患者是患有轻度非传染性疾病的患者。轻度非传染性疾病是一种临床隐匿且难以诊断的疾病,因此,筛查方法的发展和推广对于早期拦截这些受试者是必要的。
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First-level Neurocognitive Screening Tests and Their Application
Finding an effective therapy able to slow Neurocognitive Disorder’s (NCD) progression represents an ambitious purpose of biomedical research. In June 2021, the Food and Drug Administration approved Aducanumab for the treatment of Alzheimer’s disease – the most common cause of dementia worldwide [1]. This drug is a monoclonal antibody that would be cause amyloid-β plaques reduction in the brain [2]. Whether its effectiveness will be confirmed or not, the fact remains that the patients that will benefit the most from any treatment are the ones suffering from mild NCD. Mild NCD is a clinically insidious and difficult-to-diagnose disorder, and consequently, the development and the spread of screening methods are necessary to early intercept these subjects.
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