一种新的异质液滴布线技术及其模拟器,以提高数字微流控生物芯片的布线性能

Rupam Bhattacharya, H. Rahaman, P. Roy
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引用次数: 7

摘要

近年来,基于数字微流体的生物芯片(dmfb)在生化分析领域提供了一个有效的替代平台,特别是廉价、方便、不可重复使用的设备,主要用于医疗诊断应用。对于dmfb的主要类别,液滴的驱动依赖于电介质上的电润湿规则,其中纳米升体积的分离液滴可以使用二维电极阵列来操纵。dmfb中最重要的设计自动化问题是二维阵列内液滴的并发路径。液滴转向的原因是需要在一个二维阵列内以时间同步模式规划许多液滴的运动,同时最小化资源消耗并在最佳的最新到达时间内。液滴可分为均匀型和非均匀型。对于非均匀液滴路径,主要问题是避免交叉污染,而均匀液滴路径在不同路径之间共享电极以实现最小的资源利用率仍然是重点。本文提出了一种异构液滴indmfb路由算法。我们进一步开发了一个路由模拟器,可以在预定义的DMFB布局中以图形方式显示异构液滴的详细路由性能。我们使用基准套件I和III来分析我们的算法。
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A new heterogeneous droplet routing technique and its simulator to improve route performance in digital microfluidic biochips
Digital Micro fluidic based Biochips (DMFBs) in current years have provided an efficient alternative platform in the field of bio-chemical analysis, particularly for inexpensive, convenient, and not reusable devices mainly designed for medical diagnostic applications. For a major class of DMFBs droplet actuation is depend on the rule of electrowetting-on-dielectric, where separate droplets of nano liter volume can be manipulated using 2D array of electrodes. Most important design automation issues in DMFBs is the concurrent routing of droplets inside a 2D array. The reason of droplet steering is needed to plan the movement of a number of droplets in a time synchronized mode within a 2D array while minimizing resource consumption and within optimum latest arrival time. The droplets may be classified as homogeneous or heterogeneous. In case of heterogeneous droplet routing, major issue is the avoidance of cross contamination where as for homogeneous droplet routing sharing of electrodes among different route paths for minimum resource utilization remains the main focus. In our paper, we put forward an algorithm for routing of heterogeneous droplet inDMFBs. We further developed a routing simulator that graphically displays detailed route performance for heterogeneous droplets within a predefined DMFB layout. We have used benchmark suite I and III to analysis our algorithm.
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