进化序列分化预测蛋白质亚细胞定位信号

Yoshinori Fukasawa, R. Leung, S. Tsui, P. Horton
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引用次数: 2

摘要

蛋白质亚细胞定位是理解细胞生物学的一个核心问题,一直是研究的热点。为了从氨基酸序列预测定位,已经尝试了无数的特征:包括氨基酸组成,序列相似性,某些基序或结构域的存在,以及许多其他。
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Evolutionary sequence divergence predicts protein sub-cellular localization signals
Protein sub-cellular localization is a central problem in understanding cell biology and has been the focus of intense research. In order to predict localization from amino acid sequence a myriad of features have been tried: including amino acid composition, sequence similarity, the presence of certain motifs or domains, and many others.
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