HOPS捆绑复合物是维持信号内体身份和TORC1活性所必需的

The Journal of Cell Biology Pub Date : 2022-04-11 DOI:10.1083/jcb.202109084

Jieqiong Gao, Raffaele Nicastro, Marie-Pierre Péli-Gulli, Sophie Grziwa, Zilei Chen, Rainer Kurre, J. Piehler, C. De Virgilio, F. Fröhlich, C. Ungermann

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引用次数: 4

摘要

Gao等人表明，携带TORC1信号复合物的内体群体(他们称之为信号传导内体(signaling endosome, SEs))需要HOPS系住复合物和MVB生物发生才能形成和识别，并实现有效的TORC1信号传导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity

Gao et al. show that an endosomal population carrying the TORC1 signaling complex, which they term signaling endosomes (SEs), requires the HOPS tethering complex and MVB biogenesis for their formation and identity and for efficient TORC1 signaling.

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The Journal of Cell Biology

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