ASİPİMOKSUN DPPC MODEL MEMBRANLAR ÜZERİNDEKİ ETKİLERİNİN KALORİMETRİK İNCELENMESİ

Liposomes or model membranes are widely used basic systems which mimic biological membranes. In this study, the physical interaction between dipalmitoyl phosphatidylcholine (DPPC) and the lipid-lowering drug acipimox was investigated using Differential Scanning Calorimetry (DSC) technique depending on different acipimox concentrations and temperature. The changes in the phase transition temperature, phase transition enthalpy and phase transition curve half-height width of the model membranes were taken into account. According to the DSC results, with the addition of acipimox into pure DPPC model membranes, the main phase transition temperature curve, which is around 41 °C, shifted to slightly higher temperatures, while the pre-transition temperature curve, which is around 35 °C, did not disappear. Moreover, increasing acipimox concentrations caused a slight broadening of the DSC thermograms of the model membrane DPPC. Since it is very important to understand the pharmacological activity of drugs in biomembranes, the investigation of the interaction between lipid-lowering drug acipimox and lipids may contribute to the biological effects of acipimox at the molecular level.