Mucolytic Activity of Flavonol Isolated from The Silver Fern (Pityrogramma calomelanos)

The aim of study is to determine the mucolytic activity of flavonol compound namely 3,5,7,3’,4’pentahydroxyflavone (quercetine), isolated from acetone extract of the silver fern (P. calomelanos). The mucolytic activity assay in vitro was based on the decreasing viscosity of intestinal mucus cow. The viscosity value were analyzed statistically using one way ANOVA test, followed by LSD test to determine significant differences between treatment groups. The result of mucolytic activity test showed that isolate had mucolytic activity because it showed significant differences with negative control (phosphate buffer mucus). The isolate concentration of 0.4% had mucolytic activity which is equivalent to 0.1% acetylcysteine. Keywords—Pityrogramma calomelanos, flavonol, quercetine, mucolyic activity