用于动物研究的完全可植入和可充电的神经刺激系统

K. Paralikar, W. Santa, Rajesh Iyer, A. Thom, Xin Su, Erik Hovland, David A. Dinsmoor, Gordon Munns, Steve J. May, Erik R. Scott, T. Denison
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引用次数: 8

摘要

介绍了一种由可重复使用、四通道、全植入式可充电神经刺激器(INS)、充电器和无线控制器组成的神经刺激系统。该系统的目的是使啮齿动物和大型动物的刺激代码和模式的急性和慢性研究成为一种手段,以了解负责神经调节治疗的潜在神经科学原理,探索现有疗法的改进结果,并确定潜在的新疗法。INS的总容积为3cc,包括可充电电池、增产系统和小体积引线连接器块。无线遥测是感应式和可操作的,与控制器的距离可达60厘米,从而实现不受束缚的实时程序更新。
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A fully implantable and rechargeable neurostimulation system for animal research
A neurostimulation system consisting of a reusable, four-channel, fully-implantable rechargeable neurostimulator (INS), recharger and wireless controller is described. The intent of the system is to enable acute and chronic research with stimulation codes and patterns in rodents and large animals as a means to understand the underlying neuroscience principles responsible for neuromodulation therapy, explore improved outcomes for existing therapies and identify potential new therapies. The total volume of the INS is 3cc including the rechargeable battery, stimulation system and low volume lead connector block. Wireless telemetry is inductive and operational with up to 60 cm of separation from the controller so as to enable untethered, real-time program updates.
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