普瑞巴林治疗急慢性疼痛的疗效研究

A. Surana, U. Makandar, N. Ajay, B. Patil
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引用次数: 0

摘要

50名男女成年患者被选为研究对象。非神经性疼痛30例,其中膝关节置换术占33.3%,腕关节骨折占33.35例,肩关节手术占16.6%,下颌骨骨折占16.6%。而神经系统患者,即糖尿病神经病变,急性疼痛占3%,慢性疼痛占70%。脊髓损伤中腰椎水平损伤占60%,颈椎水平损伤占40%(均为急性)。普瑞巴林是一种非阿片类药物,对急性和慢性神经性疼痛比慢性关节炎疼痛更有效。此外,围手术期给予普瑞巴林引起的恶心、呕吐和瘙痒最小,不良反应包括镇静、头晕和视力障碍。这些发现或多或少与以前的研究一致。
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Study of Effect of Pregabaline in Acute and Chronic Pain
Fifty adult patients of both sexes are selected for the study. Thirty patients were non-neurological pain among them knee joint arthoplasty were 33.3%, wrist joint fracture 33.35, shoulder joint surgery were 16.6% and mandible fracture were 16.6%. While neurological patients i.e Diabetic neuropathy having acute pain 3%, and chronic pain were 70%. Spinal cord injury having lumbar level injury were 60%, and cervical level of spinal cord injury were 40% (both were acute). As pregabalin is a non opoid drug, which has more effective in acute and chronic neurological pain rather than chronic arthitic pain. Moreover, perioperative administration of pregabaline causes least nusea, vomiting and pruritis and adverse effect include sedation, dizziness and visual disturbance. These findings are more or less in agreement with previous studies.
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