用于芬太尼及相关合成阿片类药物检测的纸基微流体装置的表征

M. S. Rahman, U. Chakravarty
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摘要

本文设计并分析了一种用于芬太尼及相关合成阿片类药物检测的纸基微流控分析装置(μPAD)。芬太尼是一种合成阿片类药物,是一种作用极快的合成麻醉镇痛药,其效力约为吗啡的100至200倍。芬太尼的检测可以通过比色法进行,即用纸条和μ pad进行现场测试,这种方法具有速度快、操作简单、便携性和可负担性。液体样品和纸张在μ pad和试纸条中的微流控行为在药物检测方法中起着重要的作用。因此,本研究包含了3D打印测试装置的制作和纸基芬太尼测试装置的微流控行为分析。建立了三维微通道的多相计算流体动力学(CFD)模型,以评估微通道的微流体特性。CFD模型结合纤维素和芬太尼溶液的性质,采用流体体积法确定流动参数。采用卢卡斯-沃什伯恩方程和达西定律,对纤维素纸的吸湿过程进行了分析研究。用自制的μPAD和商用测试套件样品进行了实验,并将实验结果与数值模拟所得的流动参数进行了比较。
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Characterizations of the Paper-Based Microfluidic Devices Used for Detecting Fentanyl and Related Synthetic Opioids
The design and analysis of a paper-based microfluidic analytical device (μPAD) are presented in this paper for the detection of fentanyl and related synthetic opioids. Fentanyl, a synthetic opioid, is an extremely fast-acting synthetic narcotic analgesic having a high potency of approximately 100 to 200 times that of morphine. Detection of fentanyl can be done by colorimetric assays, i.e., spot tests with paper strips and μPADs which offer speed, simplicity of operation, portability, and affordability. The microfluidic behavior of liquid specimen and paper in the μPADs and test strips play a significant role in drug detection methods. Therefore, the study contains the fabrication of the test device using 3D printing and analysis of microfluidic behavior of the paper-based fentanyl test device. A multiphase computational fluid dynamics (CFD) model of a 3D microchannel is developed to evaluate the microfluidic properties. The CFD model incorporates the properties of cellulose and fentanyl solution to determine the flow parameters using the volume of fluid method. Wicking in the cellulose paper is studied analytically considering the Lucas-Washburn equation and Darcy’s law. Experiments with the fabricated μPAD and commercial test-kit samples are also conducted to compare the experimental results with the results for the flow parameters found from the numerical simulation.
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