Wearable Artificial Kidney Design Principles

Wearable artificial kidney (WAK) can change the approach to artificial blood purification and overcome disadvantages of hemodialysis and peritoneal dialysis. WAK implements combination of dialysate regeneration methods that are sorption with electrolysis or enzymatic urea elimination. The aim of work is to determine main requirements and basic approaches of WAK development. Tasks: develop test bench and conduct experiments for evaluation of electrochemical and enzymatic dialysate regeneration methods. Results: combination of sorption and electrolysis remove urea more intensively than complex sorption column with urease, while keeping stable ion balance. Scientific novelty: direct comparison of electrolysis and enzymatic method of waste dialysate regeneration in aspects of ion balance and urea elimination.