随着年龄的增长,人类大脑中基因表达的变化

Lilach Soreq
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摘要

衰老是包括人类在内的所有生物的普遍现象。迄今为止,很少有研究关注衰老过程中人类大脑中RNA表达的变化。特别是,我分析了神经元和神经胶质细胞类型标记基因的差异表达基于外显子微阵列数据从总体1234个死后个体大脑样本(16岁至100岁以上)和10个大脑区域。我还使用高分辨率成像和机器学习分析来量化神经元和少突胶质细胞。我的研究对人类大脑衰老过程中细胞类型特异性基因表达的变化有了深入的了解。
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Gene Expression Changes in the Human Brain Upon Aging
Aging is common to all living organisms including human. Very few studies so far focused on RNA expression changes in the human brain upon aging. In particular, I have analysed neuronal and glial cell type marker genes for differential expression based on exon microarray data from overall 1,234 postmortem individual brain samples (ages 16 to over 100) and 10 brain regions. I also quantified neurons and oligodendrocytes using high resolution imaging and machine learning analyses. My study yielded insights into cell type specific gene expression changes in aging in the human brain.
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