Pharmacotechnological Investigations of the Hedysarum caucasicum from the Northern Caucasus

The main active component of species of the genus Hedysarum are xanthones, the main of them is C-glycoside-mangiferin, which was found in the aerial part of 17 species of Hedysarum. Mangiferin is contained in plants of the genus Hedysarum can serve as a chemotaxonomic marker of this section, it has antiviral activity against DNA-containing viruses: Herpes simplex virus, Varicella zoster, Cytomegalovirus, also has immunostimulatory properties (stimulates cellular and humoral immunity). We have prepared the phytochemical investigations of xanthones. The quantitative maintenance of the sum of xanthones in terms of a specific indicator of a mangiferin is established. The technology of a liquid extract by means of 80% of ethanol is developed, technological parameters of raw materials have been determined: content of extractive substances in raw materials (26.59%); finished product removal factor (2.48); feed absorption coefficient (3.00); Internal juice formation rate (3.37); coefficient of volume increase at dissolution of extractive substances (2,013); bulk density (0.21); dry feed filling ratio (3.7); Swollen feed filling ratio (1.3); Displacement factor (1.7). Extract of Hedysarum caucasicum is obtained with ratio of phases 1:2 in a battery of 6 diffusers. It is established that extract of Hedysarum caucasicum shows the antimicrobial activity concerning Shigella sonnei, Bacillus subtilis and B. anthracoides.