CRN-based design methodology for synchronous sequential logic

With the aid of a storage-release mechanism named key-keysmith, an implementation approach based on chemical reaction networks (CRNs) for synchronous sequential logic is proposed. This design approach, which stores logic information in keysmith and releases it through key, primarily focuses on the underlying state transitions behind the required logic rather than the electronic circuit representation. Therefore, it can be uniformly and easily employed to implement any synchronous sequential logic with molecular reactions. Theoretical analysis and numerical simulations have demonstrated the robustness and universality of the proposed approach.