Pengfei Li , Jingjing Xu , Yujie Guo , Xiaojun Ma , Shaobo Zhou , Chi Zhang , Huiyan Yu , Ying Wang , Xixiang Wang , Linhong Yuan
{"title":"血浆维生素 A 水平与 2 型糖尿病的关系：一项基于社区老龄人口的横断面研究","authors":"Pengfei Li , Jingjing Xu , Yujie Guo , Xiaojun Ma , Shaobo Zhou , Chi Zhang , Huiyan Yu , Ying Wang , Xixiang Wang , Linhong Yuan","doi":"10.26599/FSHW.2022.9250173","DOIUrl":null,"url":null,"abstract":"<div><p>Recent studies indicated that vitamin A (VA) might be involved in the pathology of type 2 diabetes mellitus (T2DM). This cross-sectional study was conducted to explore the association between circulating VA level and T2DM. A total of 1 818 subjects aged 50 years old and above were recruited from the community. Binomial logistic regression and restricted cubic spline (RCS) were applied to analyze the association of plasma VA level with the risk of T2DM. Serum VA and lipid-adjusted VA levels of T2DM patients were significantly higher than that of non-T2DM subjects (<em>P</em> < 0.05). The ratios of plasma VA/total cholesterol (TC), VA/high-density lipoprotein cholesterol (HDL-c) and VA/low-density lipoprotein cholesterol (LDL-c) were positively associated with the risk of T2DM in the aging population (<em>P</em> < 0.05). Compared with the Q1 level, subjects with Q2 to Q3 levels of plasma VA/triglyceride (TG) have decreased risk of T2DM (odds ratio (OR)<sub>Q2</sub> = 0.68, <em>P</em><sub>Q2</sub> = 0.021; OR<sub>Q3</sub> = 0.59, <em>P</em><sub>Q3</sub> < 0.01). Our results indicated that the imbalance of circulating lipids and VA might affect the relationship between VA and T2DM. The middle and aging subjects with higher ratios of plasma VA/TC, VA/HDL-c, and VA/LDL-c displayed increased risk for T2DM, but the moderate ratio of VA/TG might protect against risk of T2DM.</p></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 4","pages":"Pages 2079-2089"},"PeriodicalIF":5.6000,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213453024000909/pdfft?md5=addafef39a42fc845cf765795f129a6b&pid=1-s2.0-S2213453024000909-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Association of plasma vitamin A level with type 2 diabetes mellitus: a community aging population-based cross-sectional study\",\"authors\":\"Pengfei Li , Jingjing Xu , Yujie Guo , Xiaojun Ma , Shaobo Zhou , Chi Zhang , Huiyan Yu , Ying Wang , Xixiang Wang , Linhong Yuan\",\"doi\":\"10.26599/FSHW.2022.9250173\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Recent studies indicated that vitamin A (VA) might be involved in the pathology of type 2 diabetes mellitus (T2DM). This cross-sectional study was conducted to explore the association between circulating VA level and T2DM. A total of 1 818 subjects aged 50 years old and above were recruited from the community. Binomial logistic regression and restricted cubic spline (RCS) were applied to analyze the association of plasma VA level with the risk of T2DM. Serum VA and lipid-adjusted VA levels of T2DM patients were significantly higher than that of non-T2DM subjects (<em>P</em> < 0.05). The ratios of plasma VA/total cholesterol (TC), VA/high-density lipoprotein cholesterol (HDL-c) and VA/low-density lipoprotein cholesterol (LDL-c) were positively associated with the risk of T2DM in the aging population (<em>P</em> < 0.05). Compared with the Q1 level, subjects with Q2 to Q3 levels of plasma VA/triglyceride (TG) have decreased risk of T2DM (odds ratio (OR)<sub>Q2</sub> = 0.68, <em>P</em><sub>Q2</sub> = 0.021; OR<sub>Q3</sub> = 0.59, <em>P</em><sub>Q3</sub> < 0.01). Our results indicated that the imbalance of circulating lipids and VA might affect the relationship between VA and T2DM. The middle and aging subjects with higher ratios of plasma VA/TC, VA/HDL-c, and VA/LDL-c displayed increased risk for T2DM, but the moderate ratio of VA/TG might protect against risk of T2DM.</p></div>\",\"PeriodicalId\":12406,\"journal\":{\"name\":\"Food Science and Human Wellness\",\"volume\":\"13 4\",\"pages\":\"Pages 2079-2089\"},\"PeriodicalIF\":5.6000,\"publicationDate\":\"2024-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2213453024000909/pdfft?md5=addafef39a42fc845cf765795f129a6b&pid=1-s2.0-S2213453024000909-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Science and Human Wellness\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213453024000909\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Science and Human Wellness","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213453024000909","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Association of plasma vitamin A level with type 2 diabetes mellitus: a community aging population-based cross-sectional study
Recent studies indicated that vitamin A (VA) might be involved in the pathology of type 2 diabetes mellitus (T2DM). This cross-sectional study was conducted to explore the association between circulating VA level and T2DM. A total of 1 818 subjects aged 50 years old and above were recruited from the community. Binomial logistic regression and restricted cubic spline (RCS) were applied to analyze the association of plasma VA level with the risk of T2DM. Serum VA and lipid-adjusted VA levels of T2DM patients were significantly higher than that of non-T2DM subjects (P < 0.05). The ratios of plasma VA/total cholesterol (TC), VA/high-density lipoprotein cholesterol (HDL-c) and VA/low-density lipoprotein cholesterol (LDL-c) were positively associated with the risk of T2DM in the aging population (P < 0.05). Compared with the Q1 level, subjects with Q2 to Q3 levels of plasma VA/triglyceride (TG) have decreased risk of T2DM (odds ratio (OR)Q2 = 0.68, PQ2 = 0.021; ORQ3 = 0.59, PQ3 < 0.01). Our results indicated that the imbalance of circulating lipids and VA might affect the relationship between VA and T2DM. The middle and aging subjects with higher ratios of plasma VA/TC, VA/HDL-c, and VA/LDL-c displayed increased risk for T2DM, but the moderate ratio of VA/TG might protect against risk of T2DM.
期刊介绍：
Food Science and Human Wellness is an international peer-reviewed journal that provides a forum for the dissemination of the latest scientific results in food science, nutriology, immunology and cross-field research. Articles must present information that is novel, has high impact and interest, and is of high scientific quality. By their effort, it has been developed to promote the public awareness on diet, advocate healthy diet, reduce the harm caused by unreasonable dietary habit, and directs healthy food development for food industrial producers.
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