不同剂量的葡萄糖和果糖对人体中枢碳代谢途径和细胞间无线通信网络的影响

IF 5.6 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Food Science and Human Wellness Pub Date : 2024-05-27 DOI:10.26599/FSHW.2022.9250158
Dingqiang Lu , Yujiao Liu , Miao Zhao , Shuai Yuan , Danyang Liu , Xinqian Wang , Yixuan Liu , Yifei Zhang , Ming Li , Yufeng Lü , Guangchang Pang , Ruijuan Ren
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摘要

果糖和葡萄糖经常被广泛用于食品加工,可能会导致许多代谢性疾病。为了观察不同剂量的葡萄糖和果糖对人体代谢和细胞通讯的影响,志愿者分别服用了低、中、高剂量的葡萄糖和果糖。检测了血清细胞因子、葡萄糖、乳酸、烟酰胺腺嘌呤二核苷酸(NADH)和代谢酶,并构建了中心碳代谢途径网络和细胞因子通讯网络。结果表明,随着剂量的增加,葡萄糖组和果糖组基本保持了分解代谢减少、合成代谢增加的趋势。与葡萄糖相比,低剂量果糖减少了分解代谢,增加了合成代谢,显著提高了炎性细胞因子干扰素-γ(IFN-γ)、巨噬细胞源趋化因子(MDC)、诱导蛋白-10(IP-10)和Eotaxin的表达,显著降低了异柠檬酸脱氢酶(ICDH)和丙酮酸脱氢酶复合物(PDHC)的活性。中剂量和高剂量果糖都会增加分解代谢和合成代谢,并且有更多的细胞因子和酶发生明显变化。此外,多种细胞因子和酶通过改变中心碳代谢途径中酶的转录和表达,显示出与代谢调节密切相关。因此,应减少果糖的过量摄入,以避免过度的炎症反应、过敏反应和自身免疫性疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Effects of different doses of glucose and fructose on central carbon metabolic pathways and intercellular wireless communication networks in humans

Fructose and glucose are often widely used in food processing and may contribute to many metabolic diseases. To observe the effects of different doses of glucose and fructose on human metabolism and cellular communication, volunteers were given low, medium, and high doses of glucose and fructose. Serum cytokines, glucose, lactate, nicotinamide adenine dinucleotide (NADH) and metabolic enzymes were assayed, and central carbon metabolic pathway networks and cytokine communication networks were constructed. The results showed that the glucose and fructose groups basically maintained the trend of decreasing catabolism and increasing anabolism with increasing dose. Compared with glucose, low-dose fructose decreased catabolism and increased anabolism, significantly enhanced the expression of the inflammatory cytokine interferon-γ (IFN-γ), macrophage-derived chemokine (MDC), induced protein-10 (IP-10), and eotaxin, and significantly reduced the activity of isocitrate dehydrogenase (ICDH) and pyruvate dehydrogenase complexes (PDHC). Both medium and high doses of fructose increase catabolism and anabolism, and there are more cytokines and enzymes with significant changes. Furthermore, multiple cytokines and enzymes show strong relevance to metabolic regulation by altering the transcription and expression of enzymes in central carbon metabolic pathways. Therefore, excessive intake of fructose should be reduced to avoid excessive inflammatory responses, allergic reactions and autoimmune diseases.

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来源期刊
Food Science and Human Wellness
Food Science and Human Wellness Agricultural and Biological Sciences-Food Science
CiteScore
8.30
自引率
5.70%
发文量
80
审稿时长
28 days
期刊介绍: Food Science and Human Wellness is an international peer-reviewed journal that provides a forum for the dissemination of the latest scientific results in food science, nutriology, immunology and cross-field research. Articles must present information that is novel, has high impact and interest, and is of high scientific quality. By their effort, it has been developed to promote the public awareness on diet, advocate healthy diet, reduce the harm caused by unreasonable dietary habit, and directs healthy food development for food industrial producers.
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