服用益生菌可减轻睡眠不足引起的认知障碍和昼夜节律紊乱

IF 5.6 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Food Science and Human Wellness Pub Date : 2024-05-27 DOI:10.26599/FSHW.2022.9250162
Peijun Tian , Yunfei Hou , Zheng Wang , Jiaona Jiang , Xin Qian , Zhihao Qu , Jianxin Zhao , Gang Wang , Wei Chen
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引用次数: 0

摘要

肠道微生物群对维持正常的大脑功能不可或缺。具体来说,肠道微生物群在睡眠剥夺(SD)诱导的认知障碍中起着因果作用。本研究评估了双歧杆菌菌株(CCFM1025)对睡眠不足小鼠神经行为的影响。CCFM1025改善了小鼠的体重以及食物和水的摄入量。它还缓解了SD诱导的认知行为异常(在新物体识别测试中),但对情绪和空间记忆相关行为并未显示出有益影响。CCFM1025明显改变了肠道微生物组成和基因组功能。研究还发现了可能调节睡眠功能的关键微生物代谢物,如肠道中的异戊酸和γ-氨基丁酸以及血清中的嘌呤代谢物。这些代谢物可能通过作用于纹状体褪黑激素系统(例如提高褪黑激素水平)和调节昼夜节律时钟基因(例如编码腺苷 A2A 受体和周期昼夜节律调节器 1 的基因)的表达,参与肠道与大脑的交流。总之,通过调节肠道微生物组及其代谢产物,服用益生菌可减轻自毁性脑损伤引起的认知障碍和昼夜节律紊乱。这些发现可能有助于指导通过饮食策略治疗失眠或其他睡眠障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation

Gut microbiome is indispensable for maintaining normal brain function. Specifically, gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment. In this study, neurobehavioral effects of the Bifidobacterium breve strain (CCFM1025) were assessed in sleep-deprived mice. CCFM1025 improved the body weight and food and water intake of the mice. It also alleviated SD-induced cognitive behavioural abnormalities (in the novel object recognition test), but did not show beneficial effects on mood- and spatial memory-related behaviours. CCFM1025 significantly altered the gut microbial composition and genome function. Key microbial metabolites that may regulate sleep function were also identified, such as isovaleric acid and γ-aminobutyric acid in the gut and purine metabolites in the serum. Those metabolites may participate in gut-brain communication by acting on the striatal melatonin system, for example to increase melatonin levels, and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator 1. Collectively, administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its metabolites. These findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.

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来源期刊
Food Science and Human Wellness
Food Science and Human Wellness Agricultural and Biological Sciences-Food Science
CiteScore
8.30
自引率
5.70%
发文量
80
审稿时长
28 days
期刊介绍: Food Science and Human Wellness is an international peer-reviewed journal that provides a forum for the dissemination of the latest scientific results in food science, nutriology, immunology and cross-field research. Articles must present information that is novel, has high impact and interest, and is of high scientific quality. By their effort, it has been developed to promote the public awareness on diet, advocate healthy diet, reduce the harm caused by unreasonable dietary habit, and directs healthy food development for food industrial producers.
期刊最新文献
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