Total Synthesis of Resin Glycoside Merremoside D Using Key Glycosylation Methodologies

Resin glycosides are known as glycolipids isolated from plants of the Convolvulaceae families, which have been used as major constituents of traditional folk medicines. However, their isolation, structure determination, and biological activities have been hampered due to poor production because of their complicated structural diversity. In this short review, total synthesis of resin glycoside merremoside D by two research groups is described.