亚急性给药洋葱废槲皮素对小鼠海马的组织学影响

IF 1 Q3 MULTIDISCIPLINARY SCIENCES gazi university journal of science Pub Date : 2023-08-26 DOI:10.35378/gujs.1272285
Nathan DİBAL, Musa SAMAİLA CHİROMA, Martha ATTAH, Sunday MANYE
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引用次数: 0

摘要

槲皮素是一种黄酮类化合物,具有很强的穿越血脑屏障的能力。据报道,它对动物和人类健康都有许多有益的影响。研究了洋葱废槲皮素(OWQ)对小鼠海马和齿状回组织学的影响。将20只小鼠分为4组(n=5)。各组分别给予蒸馏水95mg/kg、190mg/kg、380mg/kg的OWQ,连续28 d。每只老鼠的大脑随后被采集,称重,并进行光学显微镜处理。齿状回和海马的正常细胞和退化细胞(CA1 &计算CA3)。对照小鼠的齿状回显微图显示正常的分子层、颗粒层和多形层,而OWQ (190mg/kg)处理小鼠的齿状回颗粒层中变性细胞较少。owq处理小鼠海马CA3区显示正常的分子层和多态层。然而,给药剂量为190mg/kg的小鼠颗粒层出现大量变性细胞。特别是95mg/kg的OWQ显著增加了齿状回和海马(CA1 &脑CA3)与对照组相比;. 05。与对照组相比,它还显著减少了退化细胞(P<. 05)。综上所述,洋葱废槲皮素可维持小鼠脑齿状回和海马内的正常细胞池,特别是在95mg/kg时。
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Effects of Sub-acute Administration of Onion Waste Quercetin on the Hippocampus of Mice: A Histological Approach
Quercetin is a flavonoid with a great capability of crossing the blood-brain barrier. It is reported to exert numerous beneficial effects on both animal and human health. The study evaluates the effects of onion waste quercetin (OWQ) on the histology of the hippocampus and dentate gyrus of mice. Twenty mice were assigned into four groups (n=5). The groups were given distilled water, and OWQ at 95mg/kg, 190mg/kg, and 380mg/kg respectively for 28 days. The brain of each mouse was harvested afterward, weighed, and processed for light microscopy. The normal and degenerating cells in the dentate gyrus and hippocampus Cornu Ammonis (CA1 & CA3) were counted. The micrographs of the dentate gyrus showed normal molecular, granular, and polymorphic layers in the control mice, as well as the mice, treated with OWQ with few degenerating cells in the granular layer of OWQ-treated (190mg/kg) mice. The CA3 area of the hippocampus showed normal molecular and polymorphic layers in OWQ-treated mice. However, the granular layer of the mice that received OWQ at 190mg/kg showed numerous degenerating cells. OWQ especially at 95mg/kg was found to significantly increase the number of normal cells in the dentate gyrus and hippocampus (CA1 & CA3) of the brain compared to the control at P< .05. It also significantly decreased degenerating cells compared to the control (P< .05). In conclusion, onion waste quercetin, especially at 95mg/kg was found to maintain the pool of normal cells within the dentate gyrus and hippocampus of mice brain.
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来源期刊
gazi university journal of science
gazi university journal of science MULTIDISCIPLINARY SCIENCES-
CiteScore
1.60
自引率
11.10%
发文量
87
期刊介绍: The scope of the “Gazi University Journal of Science” comprises such as original research on all aspects of basic science, engineering and technology. Original research results, scientific reviews and short communication notes in various fields of science and technology are considered for publication. The publication language of the journal is English. Manuscripts previously published in another journal are not accepted. Manuscripts with a suitable balance of practice and theory are preferred. A review article is expected to give in-depth information and satisfying evaluation of a specific scientific or technologic subject, supported with an extensive list of sources. Short communication notes prepared by researchers who would like to share the first outcomes of their on-going, original research work are welcome.
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