Nathan DİBAL, Musa SAMAİLA CHİROMA, Martha ATTAH, Sunday MANYE
{"title":"亚急性给药洋葱废槲皮素对小鼠海马的组织学影响","authors":"Nathan DİBAL, Musa SAMAİLA CHİROMA, Martha ATTAH, Sunday MANYE","doi":"10.35378/gujs.1272285","DOIUrl":null,"url":null,"abstract":"Quercetin is a flavonoid with a great capability of crossing the blood-brain barrier. It is reported to exert numerous beneficial effects on both animal and human health. The study evaluates the effects of onion waste quercetin (OWQ) on the histology of the hippocampus and dentate gyrus of mice. Twenty mice were assigned into four groups (n=5). The groups were given distilled water, and OWQ at 95mg/kg, 190mg/kg, and 380mg/kg respectively for 28 days. The brain of each mouse was harvested afterward, weighed, and processed for light microscopy. The normal and degenerating cells in the dentate gyrus and hippocampus Cornu Ammonis (CA1 & CA3) were counted. The micrographs of the dentate gyrus showed normal molecular, granular, and polymorphic layers in the control mice, as well as the mice, treated with OWQ with few degenerating cells in the granular layer of OWQ-treated (190mg/kg) mice. The CA3 area of the hippocampus showed normal molecular and polymorphic layers in OWQ-treated mice. However, the granular layer of the mice that received OWQ at 190mg/kg showed numerous degenerating cells. OWQ especially at 95mg/kg was found to significantly increase the number of normal cells in the dentate gyrus and hippocampus (CA1 & CA3) of the brain compared to the control at P< .05. It also significantly decreased degenerating cells compared to the control (P< .05). In conclusion, onion waste quercetin, especially at 95mg/kg was found to maintain the pool of normal cells within the dentate gyrus and hippocampus of mice brain.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Sub-acute Administration of Onion Waste Quercetin on the Hippocampus of Mice: A Histological Approach\",\"authors\":\"Nathan DİBAL, Musa SAMAİLA CHİROMA, Martha ATTAH, Sunday MANYE\",\"doi\":\"10.35378/gujs.1272285\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Quercetin is a flavonoid with a great capability of crossing the blood-brain barrier. It is reported to exert numerous beneficial effects on both animal and human health. The study evaluates the effects of onion waste quercetin (OWQ) on the histology of the hippocampus and dentate gyrus of mice. Twenty mice were assigned into four groups (n=5). The groups were given distilled water, and OWQ at 95mg/kg, 190mg/kg, and 380mg/kg respectively for 28 days. The brain of each mouse was harvested afterward, weighed, and processed for light microscopy. The normal and degenerating cells in the dentate gyrus and hippocampus Cornu Ammonis (CA1 & CA3) were counted. The micrographs of the dentate gyrus showed normal molecular, granular, and polymorphic layers in the control mice, as well as the mice, treated with OWQ with few degenerating cells in the granular layer of OWQ-treated (190mg/kg) mice. The CA3 area of the hippocampus showed normal molecular and polymorphic layers in OWQ-treated mice. However, the granular layer of the mice that received OWQ at 190mg/kg showed numerous degenerating cells. OWQ especially at 95mg/kg was found to significantly increase the number of normal cells in the dentate gyrus and hippocampus (CA1 & CA3) of the brain compared to the control at P< .05. It also significantly decreased degenerating cells compared to the control (P< .05). In conclusion, onion waste quercetin, especially at 95mg/kg was found to maintain the pool of normal cells within the dentate gyrus and hippocampus of mice brain.\",\"PeriodicalId\":12615,\"journal\":{\"name\":\"gazi university journal of science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2023-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"gazi university journal of science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35378/gujs.1272285\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"gazi university journal of science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35378/gujs.1272285","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Effects of Sub-acute Administration of Onion Waste Quercetin on the Hippocampus of Mice: A Histological Approach
Quercetin is a flavonoid with a great capability of crossing the blood-brain barrier. It is reported to exert numerous beneficial effects on both animal and human health. The study evaluates the effects of onion waste quercetin (OWQ) on the histology of the hippocampus and dentate gyrus of mice. Twenty mice were assigned into four groups (n=5). The groups were given distilled water, and OWQ at 95mg/kg, 190mg/kg, and 380mg/kg respectively for 28 days. The brain of each mouse was harvested afterward, weighed, and processed for light microscopy. The normal and degenerating cells in the dentate gyrus and hippocampus Cornu Ammonis (CA1 & CA3) were counted. The micrographs of the dentate gyrus showed normal molecular, granular, and polymorphic layers in the control mice, as well as the mice, treated with OWQ with few degenerating cells in the granular layer of OWQ-treated (190mg/kg) mice. The CA3 area of the hippocampus showed normal molecular and polymorphic layers in OWQ-treated mice. However, the granular layer of the mice that received OWQ at 190mg/kg showed numerous degenerating cells. OWQ especially at 95mg/kg was found to significantly increase the number of normal cells in the dentate gyrus and hippocampus (CA1 & CA3) of the brain compared to the control at P< .05. It also significantly decreased degenerating cells compared to the control (P< .05). In conclusion, onion waste quercetin, especially at 95mg/kg was found to maintain the pool of normal cells within the dentate gyrus and hippocampus of mice brain.
期刊介绍:
The scope of the “Gazi University Journal of Science” comprises such as original research on all aspects of basic science, engineering and technology. Original research results, scientific reviews and short communication notes in various fields of science and technology are considered for publication. The publication language of the journal is English. Manuscripts previously published in another journal are not accepted. Manuscripts with a suitable balance of practice and theory are preferred. A review article is expected to give in-depth information and satisfying evaluation of a specific scientific or technologic subject, supported with an extensive list of sources. Short communication notes prepared by researchers who would like to share the first outcomes of their on-going, original research work are welcome.