减肥手术治疗非酒精性脂肪肝的前景

V. A. Akhmedov
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引用次数: 0

摘要

世界范围内的肥胖流行伴随着非酒精性脂肪性肝病(NAFLD)病例数量的显著增加。其中一个方向是减肥手术。这篇综述文章分析了在NAFLD患者中使用减肥手术方法的短期和长期有效性。注意到减肥手术对肝纤维化生化和组织学参数的影响,胰岛素抵抗和脂质谱的变化,参与肠-肝轴稳态的肠道微生物群。基因多态性在NAFLD进展中的作用,以及对术后患者纤维化变化的保护。
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Prospects of bariatric surgery in management of patients with non-alcoholic fatty liver disease
The obesity epidemic in the world is accompanied by a significant increase in the number of cases of non-alcoholic fatty liver disease (NAFLD). One of the directions is bariatric surgery. The review article presents an analysis of the short-term and long-term effectiveness of the use of bariatric surgery methods in patients with NAFLD. Aspects of the influence of bariatric surgery on biochemical and histological parameters of liver fibrosis, changes in insulin resistance and lipid profile, intestinal microbiome involved in the homeostasis of the intestine-liver axis are noted. The role of gene polymorphisms in the progression of NAFLD, as well as protection from fibrotic changes in patients with postoperative period is presented.
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