Pub Date : 2023-11-11DOI: 10.33667/2078-5631-2023-25-56-61
M. A. Shapkin, M. A. Loginov, R. A. Cherpakov, I. Yu. Sholin, V. S. Suryakhin, A. K. Shabanov, A. V. Salikov
Introduction. Pain in the intensive care unit is a common problem in patients with acute pancreatitis of various etiologies. Given the severity of the pain syndrome, as well as the low effectiveness of nonsteroidal anti-inflammatory drugs or antispasmodic therapy, it is often necessary to resort to the administration of opioid analgesics or epidural analgesia. Each of these pain management methods has certain disadvantages and contraindications, which makes it urgent to search for a safe and effective method of relieving pain in patients with pancreatitis or pancreonecrosis.Goal. To determine the effectiveness blockade of the nerves of the fascial space of the muscles’ erector spine in acute pancreatitis. Clinical observation. Patient X., 58 years old, was arrived to the emergency department of the V.M. Buyanov State Clinical Hospital with severe pain in the epigastric region (10 points out of 10 on the visual-analog scale).Conclusions. ESPB in a patient with acute biliary pancreatitis complicated by pancreonecrosis allowed to control pain syndrome quickly and safely. Further randomized clinical trials will allow to implement and optimize the technique, improving the clinical outcome.
{"title":"Case report of ultrasound-assisted nerve blockade of fascial plane by erector spine block in acute pancreatitis","authors":"M. A. Shapkin, M. A. Loginov, R. A. Cherpakov, I. Yu. Sholin, V. S. Suryakhin, A. K. Shabanov, A. V. Salikov","doi":"10.33667/2078-5631-2023-25-56-61","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-25-56-61","url":null,"abstract":"Introduction. Pain in the intensive care unit is a common problem in patients with acute pancreatitis of various etiologies. Given the severity of the pain syndrome, as well as the low effectiveness of nonsteroidal anti-inflammatory drugs or antispasmodic therapy, it is often necessary to resort to the administration of opioid analgesics or epidural analgesia. Each of these pain management methods has certain disadvantages and contraindications, which makes it urgent to search for a safe and effective method of relieving pain in patients with pancreatitis or pancreonecrosis.Goal. To determine the effectiveness blockade of the nerves of the fascial space of the muscles’ erector spine in acute pancreatitis. Clinical observation. Patient X., 58 years old, was arrived to the emergency department of the V.M. Buyanov State Clinical Hospital with severe pain in the epigastric region (10 points out of 10 on the visual-analog scale).Conclusions. ESPB in a patient with acute biliary pancreatitis complicated by pancreonecrosis allowed to control pain syndrome quickly and safely. Further randomized clinical trials will allow to implement and optimize the technique, improving the clinical outcome.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"3 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-11DOI: 10.33667/2078-5631-2023-25-44-49
M. I. Neimark, A. A. Burenkin, N. G. Khorev, M. G. Nikolaev
Objective. To improve the results of treatment of comorbid patients with acute arterial ischemia by substantiating the optimal type of spinal anesthesia for surgical intervention on the affected limb.Materials and methods. The study involved 70 patients who were treated in the Department of Vascular Surgery of Clinical Hospital of ‘Russian Railways-Medicine Co.’ in Barnaul. The patients were divided into two groups: group 1 – patients operated under conditions of bilateral (bilateral) spinal anesthesia, group 2 – patients operated under conditions of monolateral (unilateral) spinal anesthesia. All patients underwent an assessment of the level of spinal block on the Bromage scale, monitoring of central hemodynamics using a MARG-10–01 rheograph, postoperative assessment of myocardial ischemia on the ECG, acute kidney damage to control diuresis.Results. In the 2nd group, there was a sufficient sensory and motor block to perform surgery. In the intraoperative period in the group of patients who underwent unilateral blockade, the mean arterial pressure decreased by 3 mm Hg. In this regard, there was no clinically significant increase in heart rate and a decrease in the stroke index and the index of total peripheral vascular resistance. In the 1st group, the decrease in mean arterial pressure reached 20% of the original, which led to an increase in heart rate by 12% and a decrease in stroke index by 11%.Conclusions. During the perioperative period, the indicators of central hemodynamics in the group 2 were more stable compared to the group 1, they did not need the use of vasopressor drugs and crystalloids. And in the early postoperative period, patients who underwent unilateral anesthesia did not show signs of acute kidney injury. Monolateral spinal anesthesia, compared with conventional spinal anesthesia, provides more stable hemodynamics in elderly patients with acute arterial ischemia.
目标。为提高急性动脉缺血合并症患者的治疗效果，确定患肢手术干预的最佳脊髓麻醉类型。材料和方法。这项研究涉及70名在巴尔瑙尔“俄罗斯铁路医药公司”临床医院血管外科接受治疗的患者。患者分为两组:组1为双侧(双侧)脊髓麻醉，组2为单侧(单侧)脊髓麻醉。所有患者均接受Bromage评分评估脊髓阻滞水平，使用MARG-10-01流变仪监测中央血流动力学，术后心电图评估心肌缺血，急性肾损伤以控制利尿。在第二组中，有足够的感觉和运动障碍进行手术。单侧阻断组患者术中平均动脉压下降3 mm Hg，心率无明显升高，卒中指数和外周血管总阻力指数均无明显下降。第一组患者平均动脉压降低20%，心率提高12%，卒中指数降低11%。围手术期，2组中央血流动力学指标较1组稳定，不需要使用升压药物和晶体类药物。术后早期，单侧麻醉患者未出现急性肾损伤的迹象。与常规脊髓麻醉相比，单侧脊髓麻醉可为老年急性动脉缺血患者提供更稳定的血流动力学。
{"title":"Comparative assessment of effect of two methods of spinal anesthesia on central hemodynamic parameters in elderly and senile patients in emergency vascular surgery","authors":"M. I. Neimark, A. A. Burenkin, N. G. Khorev, M. G. Nikolaev","doi":"10.33667/2078-5631-2023-25-44-49","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-25-44-49","url":null,"abstract":"Objective. To improve the results of treatment of comorbid patients with acute arterial ischemia by substantiating the optimal type of spinal anesthesia for surgical intervention on the affected limb.Materials and methods. The study involved 70 patients who were treated in the Department of Vascular Surgery of Clinical Hospital of ‘Russian Railways-Medicine Co.’ in Barnaul. The patients were divided into two groups: group 1 – patients operated under conditions of bilateral (bilateral) spinal anesthesia, group 2 – patients operated under conditions of monolateral (unilateral) spinal anesthesia. All patients underwent an assessment of the level of spinal block on the Bromage scale, monitoring of central hemodynamics using a MARG-10–01 rheograph, postoperative assessment of myocardial ischemia on the ECG, acute kidney damage to control diuresis.Results. In the 2nd group, there was a sufficient sensory and motor block to perform surgery. In the intraoperative period in the group of patients who underwent unilateral blockade, the mean arterial pressure decreased by 3 mm Hg. In this regard, there was no clinically significant increase in heart rate and a decrease in the stroke index and the index of total peripheral vascular resistance. In the 1st group, the decrease in mean arterial pressure reached 20% of the original, which led to an increase in heart rate by 12% and a decrease in stroke index by 11%.Conclusions. During the perioperative period, the indicators of central hemodynamics in the group 2 were more stable compared to the group 1, they did not need the use of vasopressor drugs and crystalloids. And in the early postoperative period, patients who underwent unilateral anesthesia did not show signs of acute kidney injury. Monolateral spinal anesthesia, compared with conventional spinal anesthesia, provides more stable hemodynamics in elderly patients with acute arterial ischemia.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"1 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-11DOI: 10.33667/2078-5631-2023-25-32-43
P. A. Zhezhuk, A. V. Vlasenko, E. A. Evdokimov, D. I. Levikov, E. P. Rodionov, V. I. Makovey, V. V. Erofeev
Infusion therapy is an important component of many diseases treatment – and one of the main methods of intensive care for intensive care patients. Active infusion therapy using different infusion media, large volumes and high rates of intravenous fluid is especially relevant in critical patients, the most severe of which remains patients with septic shock. For more than two centuries of clinical use, infusion therapy has gone through a long evolutionary path and has become more effective and safer. However, like any drug, infusion therapy (in general and specific infusion media) has a number of side effects, especially when used excessively. Therefore, in recent years, the use of infusion therapy is considered as the appointment of any drug, taking into account indications, contraindications, methods of administration, dosing, duration, deescalation. This made it possible to identify the main stages of infusion therapy of critical conditions and shock: intensive infusion therapy (rapid administration of a large fluid volume), optimization of infusion therapy (reduction of the rate and volume of infusion), stabilization of the patient and minimization of infusion, de-resuscitation – removal of excess fluid from the body. With the development of clinical pathophysiology, the basic concepts of maintaining fluid homeostasis of the body in normal and critical conditions were revised, and the negative effects of infusion therapy at all stages of its use were studied. Therefore, in the intensive care of shock, the main clinical questions are: when to start fluid therapy, when to stop active fluid therapy, when to start fluid removal from the body, and when to stop fluid de-resuscitation. Thus, in order to implement the principle of personalized treatment, it is important to determine not only the «tolerance» of infusion therapy, but also the «sensitivity» to the infusion of a particular patient – the ability to maintain hemodynamics without the risk of fluid overload. Evaluation of routine clinical, instrumental and laboratory indicators of the state of macro- and microcirculation does not provide an opportunity to accurately answer these questions. Modern sonographic methods for monitoring central and peripheral cardiohemodynamics, ‘venous excess’ using Doppler and extended focus echocardiography allow us to assess the ‘tolerance of infusion therapy’. The implementation of this new direction will increase the efficiency and safety of infusion therapy and improve the outcomes of the critically ill patients’ treatment.
{"title":"Infusion therapy in critical patients (state of problem). Part 1","authors":"P. A. Zhezhuk, A. V. Vlasenko, E. A. Evdokimov, D. I. Levikov, E. P. Rodionov, V. I. Makovey, V. V. Erofeev","doi":"10.33667/2078-5631-2023-25-32-43","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-25-32-43","url":null,"abstract":"Infusion therapy is an important component of many diseases treatment – and one of the main methods of intensive care for intensive care patients. Active infusion therapy using different infusion media, large volumes and high rates of intravenous fluid is especially relevant in critical patients, the most severe of which remains patients with septic shock. For more than two centuries of clinical use, infusion therapy has gone through a long evolutionary path and has become more effective and safer. However, like any drug, infusion therapy (in general and specific infusion media) has a number of side effects, especially when used excessively. Therefore, in recent years, the use of infusion therapy is considered as the appointment of any drug, taking into account indications, contraindications, methods of administration, dosing, duration, deescalation. This made it possible to identify the main stages of infusion therapy of critical conditions and shock: intensive infusion therapy (rapid administration of a large fluid volume), optimization of infusion therapy (reduction of the rate and volume of infusion), stabilization of the patient and minimization of infusion, de-resuscitation – removal of excess fluid from the body. With the development of clinical pathophysiology, the basic concepts of maintaining fluid homeostasis of the body in normal and critical conditions were revised, and the negative effects of infusion therapy at all stages of its use were studied. Therefore, in the intensive care of shock, the main clinical questions are: when to start fluid therapy, when to stop active fluid therapy, when to start fluid removal from the body, and when to stop fluid de-resuscitation. Thus, in order to implement the principle of personalized treatment, it is important to determine not only the «tolerance» of infusion therapy, but also the «sensitivity» to the infusion of a particular patient – the ability to maintain hemodynamics without the risk of fluid overload. Evaluation of routine clinical, instrumental and laboratory indicators of the state of macro- and microcirculation does not provide an opportunity to accurately answer these questions. Modern sonographic methods for monitoring central and peripheral cardiohemodynamics, ‘venous excess’ using Doppler and extended focus echocardiography allow us to assess the ‘tolerance of infusion therapy’. The implementation of this new direction will increase the efficiency and safety of infusion therapy and improve the outcomes of the critically ill patients’ treatment.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"2 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-11DOI: 10.33667/2078-5631-2023-25-50-55
S. N. Galkina, A. S. Rybalko, N. I. Chaus, S. V. Smetanina, V. B. Beloborodov, N. A. Karpun, Sh. Aliev
Introduction. Hormones are traditionally not recommended in the presence of bacterial infection, as such use may lead in septic complications. However, we have found that early use of low to medium methylprednisolone doses in a specific administration mode we have developed on the basis of scientific publications and our own data may stop ARDS progression in hospitalized patients with COVID-19 associated bacterial pneumonia without complicating the bacterial process. The article looks into effects of methylprednisolone used in ‘bolus followed by continuous infusion’ mode within the complex therapy of COVID-19 associated bacterial pneumonia patients.Materials and methods. We analyzed 37 patients admitted to our hospital during the 2nd and 3rd waves of COVID-19 at later stages of the disease, complicated by bacterial pneumonia. Apart from receiving comprehensive detoxication, anti-inflammatory, antibacterial and symptomatic therapy all patients received methylprednisolone used in ‘bolus followed by continuous infusion’ mode. The data was collected at two points and statistically analyzed. Results. Positive changes in all parameters were statistically significant, and none of the patient’s developed superinfection. Total survival was 86.49%, and none of the deaths was associated with septic complications. Conclusions. Our clinical observations and statistical analysis of data suggest that the early use of methylprednisolone in the ‘bolus followed by continuous infusion mode’ was associated with discontinuation of ARDS progression and did not lead to bacterial superinfection. On the contrary, bacterial infection regress was confirmed by the laboratory findings and statistically significant. Further research is needed for a detailed study of the results we here describe.
{"title":"Positive effects of methylprednisolone continuous infusion in treatment of hospitalized patients with COVID-19 associated bacterial pneumonia","authors":"S. N. Galkina, A. S. Rybalko, N. I. Chaus, S. V. Smetanina, V. B. Beloborodov, N. A. Karpun, Sh. Aliev","doi":"10.33667/2078-5631-2023-25-50-55","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-25-50-55","url":null,"abstract":"Introduction. Hormones are traditionally not recommended in the presence of bacterial infection, as such use may lead in septic complications. However, we have found that early use of low to medium methylprednisolone doses in a specific administration mode we have developed on the basis of scientific publications and our own data may stop ARDS progression in hospitalized patients with COVID-19 associated bacterial pneumonia without complicating the bacterial process. The article looks into effects of methylprednisolone used in ‘bolus followed by continuous infusion’ mode within the complex therapy of COVID-19 associated bacterial pneumonia patients.Materials and methods. We analyzed 37 patients admitted to our hospital during the 2nd and 3rd waves of COVID-19 at later stages of the disease, complicated by bacterial pneumonia. Apart from receiving comprehensive detoxication, anti-inflammatory, antibacterial and symptomatic therapy all patients received methylprednisolone used in ‘bolus followed by continuous infusion’ mode. The data was collected at two points and statistically analyzed. Results. Positive changes in all parameters were statistically significant, and none of the patient’s developed superinfection. Total survival was 86.49%, and none of the deaths was associated with septic complications. Conclusions. Our clinical observations and statistical analysis of data suggest that the early use of methylprednisolone in the ‘bolus followed by continuous infusion mode’ was associated with discontinuation of ARDS progression and did not lead to bacterial superinfection. On the contrary, bacterial infection regress was confirmed by the laboratory findings and statistically significant. Further research is needed for a detailed study of the results we here describe.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"2 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-11DOI: 10.33667/2078-5631-2023-25-26-31
O. G. Goryacheva
Chronic kidney disease (CKD) is the most common manifestation of target organ damage in chronic heart failure (CHF). The aim of the study was to determine the risk factors associated with the course of CKD in patients with CHF infected with the human immunodeficiency virus (HIV). According to the results obtained, the prevalence of CKD among HIV-infected patients with CHF is 58.82%, which is 4 times more common than in patients with HIV infection without CHF. The dependence of glomerular filtration rate (GFR) on three main factors that reflect damage to the heart muscle – blood plasma NT-proBNP concentration, left ventricular ejection fraction (LVEF%) and left ventricular myocardial mass index (LVMI) was proved, which together, being included in the regression model, determine 42.2% of the variance of GFR values and are decisive in the development of CKD in patients with CHF on the background of HIV infection. The concentration of NT-proBNP in the blood plasma of patients with CHF equal to or greater than 683.65 pg/ml can be considered as a diagnostic criterion for the development of CKD in HIV-infected people with a sensitivity of the method of 75.0% and a specificity of 75.4%, respectively. In addition, risk factors for the development of CKD in patients with CHF and HIV infection are smoking, alcohol and drug use, a history of chronic and acute forms of coronary artery disease, atrial fibrillation, ventricular arrhythmias, diabetes mellitus, chronic viral hepatitis C, anemia and thrombocytopenia. Patients with CHF and CKD have a more rigid arterial wall – there is a significant excess of the stiffness indices of the aorta and peripheral arteries. Long-term use of antiplatelet agents, NRTIs, NNRTIs, and protease PIs may aggravate the course of CHF in HIV-infected people with CKD manifestations.
{"title":"Chronic kidney disease in patients with chronic heart failure infected with human immunodeficiency virus","authors":"O. G. Goryacheva","doi":"10.33667/2078-5631-2023-25-26-31","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-25-26-31","url":null,"abstract":"Chronic kidney disease (CKD) is the most common manifestation of target organ damage in chronic heart failure (CHF). The aim of the study was to determine the risk factors associated with the course of CKD in patients with CHF infected with the human immunodeficiency virus (HIV). According to the results obtained, the prevalence of CKD among HIV-infected patients with CHF is 58.82%, which is 4 times more common than in patients with HIV infection without CHF. The dependence of glomerular filtration rate (GFR) on three main factors that reflect damage to the heart muscle – blood plasma NT-proBNP concentration, left ventricular ejection fraction (LVEF%) and left ventricular myocardial mass index (LVMI) was proved, which together, being included in the regression model, determine 42.2% of the variance of GFR values and are decisive in the development of CKD in patients with CHF on the background of HIV infection. The concentration of NT-proBNP in the blood plasma of patients with CHF equal to or greater than 683.65 pg/ml can be considered as a diagnostic criterion for the development of CKD in HIV-infected people with a sensitivity of the method of 75.0% and a specificity of 75.4%, respectively. In addition, risk factors for the development of CKD in patients with CHF and HIV infection are smoking, alcohol and drug use, a history of chronic and acute forms of coronary artery disease, atrial fibrillation, ventricular arrhythmias, diabetes mellitus, chronic viral hepatitis C, anemia and thrombocytopenia. Patients with CHF and CKD have a more rigid arterial wall – there is a significant excess of the stiffness indices of the aorta and peripheral arteries. Long-term use of antiplatelet agents, NRTIs, NNRTIs, and protease PIs may aggravate the course of CHF in HIV-infected people with CKD manifestations.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"2 25","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-11DOI: 10.33667/2078-5631-2023-25-21-25
N. V. Teplova, A. G. Vardanyan, V. O. Grigoryan
This article describes clinical cases of patients with ischemic heart disease complicated by severe chronic heart failure during basic therapy with the inclusion of Mildronate. The results of the treatment prove the effectiveness of the use of this drug, in the form of an increase in exercise tolerance, regression of CHF phenomena, and improvement in the quality of life of patients with a burdened cardiovascular history.
{"title":"Improving quality of life in patients with CHD and CHF: Focusing on mildronate","authors":"N. V. Teplova, A. G. Vardanyan, V. O. Grigoryan","doi":"10.33667/2078-5631-2023-25-21-25","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-25-21-25","url":null,"abstract":"This article describes clinical cases of patients with ischemic heart disease complicated by severe chronic heart failure during basic therapy with the inclusion of Mildronate. The results of the treatment prove the effectiveness of the use of this drug, in the form of an increase in exercise tolerance, regression of CHF phenomena, and improvement in the quality of life of patients with a burdened cardiovascular history.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"24 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135087110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-11DOI: 10.33667/2078-5631-2023-25-61-66
M. B. Nazarenko, O. V. Makarov, E. P. Rodionov, A. V. Vlasenko, L. A. Penzina, O. L. Smolyaninov, V. I. Makovey, L. G. Shcherbakova
Acute sialoadenitis (К11.2 МКБ 10) is one of the early post-operative complications. Swelling and infiltration of the salivary glands occur within a few minutes to 24 hours after surgery. This post-operative sialadenitis resolves spontaneously within 1–5 days, but rarely it can lead to serious complications. We present the clinical case of a 62-year-old female who underwent a spinal surgery in the prone position under general anesthesia. Three hours after the operation, we noted swelling of the neck, signs of acute respiratory failure, which required observation in intensive care unit and re-intubation of the trachea. Within 72 hours, swelling and infiltration of the salivary glands decreases. The patient was extubated and transferred to the neurosurgical department. Thus, acute post-operative sialoadenitis can cause the upper airway obstruction.
{"title":"Case of acute postoperative sialoadenitis with airway obstruction after general anesthesia","authors":"M. B. Nazarenko, O. V. Makarov, E. P. Rodionov, A. V. Vlasenko, L. A. Penzina, O. L. Smolyaninov, V. I. Makovey, L. G. Shcherbakova","doi":"10.33667/2078-5631-2023-25-61-66","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-25-61-66","url":null,"abstract":"Acute sialoadenitis (К11.2 МКБ 10) is one of the early post-operative complications. Swelling and infiltration of the salivary glands occur within a few minutes to 24 hours after surgery. This post-operative sialadenitis resolves spontaneously within 1–5 days, but rarely it can lead to serious complications. We present the clinical case of a 62-year-old female who underwent a spinal surgery in the prone position under general anesthesia. Three hours after the operation, we noted swelling of the neck, signs of acute respiratory failure, which required observation in intensive care unit and re-intubation of the trachea. Within 72 hours, swelling and infiltration of the salivary glands decreases. The patient was extubated and transferred to the neurosurgical department. Thus, acute post-operative sialoadenitis can cause the upper airway obstruction.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"1 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135087233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-11DOI: 10.33667/2078-5631-2023-25-67-72
I. A. Machulina, A. E. Shestopalov, T. S. Popova
Acute gastrointestinal injury develops in more than half of all patients in the intensive care unit, regardless of the underlying pathology and it is one of the main reasons for the onset and progression of multiple organ failure and systemic inflammatory response syndrome. The severity of the acute gastrointestinal injury correlates with the risk of death. A deeper understanding of the pathogenetic mechanisms of dysfunction of the gastrointestinal tract in critically ill patients is necessary for the development and implementation of an intensive care regimen that allows to quickly restore the function of the gastrointestinal tract and break the vicious circle of pathophysiological changes, which will ultimately lead to improvement treatment outcomes for critically ill patients and reduced mortality.
{"title":"Acute gastrointestinal injury: Stages, role in formation and progression of multiple organ failure syndrome, main stages of intensive therapy (literature review)","authors":"I. A. Machulina, A. E. Shestopalov, T. S. Popova","doi":"10.33667/2078-5631-2023-25-67-72","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-25-67-72","url":null,"abstract":"Acute gastrointestinal injury develops in more than half of all patients in the intensive care unit, regardless of the underlying pathology and it is one of the main reasons for the onset and progression of multiple organ failure and systemic inflammatory response syndrome. The severity of the acute gastrointestinal injury correlates with the risk of death. A deeper understanding of the pathogenetic mechanisms of dysfunction of the gastrointestinal tract in critically ill patients is necessary for the development and implementation of an intensive care regimen that allows to quickly restore the function of the gastrointestinal tract and break the vicious circle of pathophysiological changes, which will ultimately lead to improvement treatment outcomes for critically ill patients and reduced mortality.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"25 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135087238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-09DOI: 10.33667/2078-5631-2023-28-33-36
L. N. Kostyuchenko, T. A. Vasina, A. E. Lychkova
Nutritional support is an important component of treatment in gastroenterology. This type of therapy is directly related to digestive and transport processes.The aim. To investigate the possibility of optimizing the absorption processes in the small intestine when using various natural formulations for enteral alimentation.Results. It is shown that the optimal degree of condensation of drugs is 4: 1. Inside the dry residue, you can change the ratio of proteins, lipids and carbohydrates. It is advisable to use hydrolytic digestive enzymes including the flokozim created by us. Antibacterial agents based on lactobacilli are also advisable.Conclusions. 1) The optimal medium for suction is chyme. 2) The mixture should contain no more than 80% water and about 20% dry residue. 3) Floccules are the basis for the creation of the drug flokozim 4) Lactotherapy based on optimized mixtures for enteral.
{"title":"Ways to optimize absorption processes as basis for nutritional treatment of gastroenterological pathology","authors":"L. N. Kostyuchenko, T. A. Vasina, A. E. Lychkova","doi":"10.33667/2078-5631-2023-28-33-36","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-28-33-36","url":null,"abstract":"Nutritional support is an important component of treatment in gastroenterology. This type of therapy is directly related to digestive and transport processes.The aim. To investigate the possibility of optimizing the absorption processes in the small intestine when using various natural formulations for enteral alimentation.Results. It is shown that the optimal degree of condensation of drugs is 4: 1. Inside the dry residue, you can change the ratio of proteins, lipids and carbohydrates. It is advisable to use hydrolytic digestive enzymes including the flokozim created by us. Antibacterial agents based on lactobacilli are also advisable.Conclusions. 1) The optimal medium for suction is chyme. 2) The mixture should contain no more than 80% water and about 20% dry residue. 3) Floccules are the basis for the creation of the drug flokozim 4) Lactotherapy based on optimized mixtures for enteral.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":" 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135285590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-09DOI: 10.33667/2078-5631-2023-28-23-28
Yu. P. Uspensky, Yu. A. Fominykh, O. A. Kizimova, O. S. Minina, A. P. Zavitaeva
A 27-year-old patient was transferred by an infectious disease doctor to the St. Petersburg Elizabethan Hospital with a long history of diarrhea and intoxication syndrome. A detailed examination revealed an infection with Clostridium difficile, which contributed to the progression of the disease, deterioration of well-being and, as a result, an increase in neuroticism. The clinical and endoscopic picture indicated ulcerative colitis. When reviewing the biopsy material, noncaseating epithelioid cell granulomas were found, which confirmed the diagnosis of Crohn's disease. This case demonstrates the complexity of the differential diagnosis of inflammatory bowel diseases, which determines the tactics of patient management.
{"title":"Clinical demonstration of patient with inflammatory bowel disease","authors":"Yu. P. Uspensky, Yu. A. Fominykh, O. A. Kizimova, O. S. Minina, A. P. Zavitaeva","doi":"10.33667/2078-5631-2023-28-23-28","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-28-23-28","url":null,"abstract":"A 27-year-old patient was transferred by an infectious disease doctor to the St. Petersburg Elizabethan Hospital with a long history of diarrhea and intoxication syndrome. A detailed examination revealed an infection with Clostridium difficile, which contributed to the progression of the disease, deterioration of well-being and, as a result, an increase in neuroticism. The clinical and endoscopic picture indicated ulcerative colitis. When reviewing the biopsy material, noncaseating epithelioid cell granulomas were found, which confirmed the diagnosis of Crohn's disease. This case demonstrates the complexity of the differential diagnosis of inflammatory bowel diseases, which determines the tactics of patient management.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":" 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135286297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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