{"title":"精神分裂症患者光学相干断层扫描表现的神经心理学和临床相关性","authors":"Ayşe SAKALLI KANİ, Cansun ŞAHİN ÇAM, Esra BİBEROĞLU ÇELİK, Uzay DURAL, Melike DURAN DÖNMEZ, Semra AKKAYA TURHAN, Ebru TOKER, Mesut YILDIZ","doi":"10.33808/clinexphealthsci.1331234","DOIUrl":null,"url":null,"abstract":"Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters.
 Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters.
 Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior ( ρ – .422, p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.3000,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neuropsychological and Clinical Correlations of Optical Coherence Tomography Findings in Patients with Schizophrenia\",\"authors\":\"Ayşe SAKALLI KANİ, Cansun ŞAHİN ÇAM, Esra BİBEROĞLU ÇELİK, Uzay DURAL, Melike DURAN DÖNMEZ, Semra AKKAYA TURHAN, Ebru TOKER, Mesut YILDIZ\",\"doi\":\"10.33808/clinexphealthsci.1331234\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters.
 Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters.
 Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior ( ρ – .422, p\",\"PeriodicalId\":10192,\"journal\":{\"name\":\"Clinical and Experimental Health Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2023-08-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Health Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33808/clinexphealthsci.1331234\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Health Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33808/clinexphealthsci.1331234","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
摘要
目的:对精神分裂症患者视网膜纤维层(RNFL)和神经节细胞层(GCL)变薄的研究越来越多。然而,结果是有争议的,这些发现的临床和认知反映仍然不清楚。在这项研究中,我们的目的是检查视网膜异常,并建立与认知和临床参数的相关性。
方法:在这项横断面研究中,我们检查了29例精神分裂症患者和13例年龄和性别匹配的健康对照。所有参与者都进行了心理测量评估、神经心理测试和光学相干断层扫描(OCT)测量。以视网膜纤维层和神经节细胞层厚度作为视网膜参数。
结果:5例患者在OCT测量过程中退出,24例精神分裂症患者和9例健康对照纳入分析。各组间测量视网膜神经纤维层及神经节细胞层厚度差异无统计学意义。语言流畅性测试分数与左侧RNFL优势呈负相关(ρ - 0.422, p
Neuropsychological and Clinical Correlations of Optical Coherence Tomography Findings in Patients with Schizophrenia
Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters.
Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters.
Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior ( ρ – .422, p