微波辅助凝胶纳米颗粒制备:绿茶多酚介导的交联及其增强的生物功效

IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Research Journal of Biotechnology Pub Date : 2023-09-15 DOI:10.25303/1810rjbt1640173

Karikalan Kulandaivelu, Shrila Banerjee, Abul Kalam Azad Mandal

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引用次数: 0

摘要

采用微波辅助法制备了明胶纳米颗粒(GNP)，而不使用双溶剂法中常用的极性溶剂丙酮和交联剂戊二醛。此外，我们尝试使用绿茶多酚(GTP)作为天然交联剂。颗粒呈球形，直径约98.5 nm，多分散性指数(pi)为0.813，表面电荷为-11.6 mV。微波辅助法制备了GNPs-GTP中约20%的游离氨基，包封率为69.8%。观察到主要释放符合零阶和Korsmeyer-Peppas动力学模型。

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Microwave-assisted gelatin nanoparticles preparation: Green tea polyphenol mediated cross-linking and its enhanced bio-efficacy

Gelatin nanoparticles (GNP) were successfully prepared by microwave-assisted method without using polar solvent acetone and cross-linker glutaraldehyde which are generally used in the double desolvation method. Moreover, we tried using green tea polyphenol (GTP) as a natural cross-linker. The particles were spherical, around 98.5 nm in size with a polydispersity index (P.I) of 0.813 and the surface charge was -11.6 mV. About 20% of free amino groups present in GNPs-GTP are made by microwave-assisted method with an encapsulation efficiency of 69.8 %. The predominant release was observed to fit in zero-order and Korsmeyer-Peppas kinetic models.

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来源期刊

Research Journal of Biotechnology 工程技术-生物工程与应用微生物

CiteScore

0.60

自引率

0.00%

发文量

192

审稿时长

1.5 months

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