Cerebrorenal connections in patients with chronic cerebral ischemia living in Republic of Sakha (Yakutia)

Purpose of the study . Identification of cerebrorenal relationships in patients with chronic cerebral ischemia (CCI) of elderly and senile age. Material and methods . We studied 522 elderly and senile patients with stage I and II CCI living in the Republic of Sakha (Yakutia). Doppler ultrasound was the main method for studying cerebral hemodynamics in this work. Glomerular filtration rate (GFR), which is the most reliable integral measure of the functional state of the kidneys, was calculated using the CKD-EPI formula, which takes into account race, gender, age, and serum creatinine levels. Results . Between the value of the glomerular filtration rate and almost all ultrasonic indicators included in the analysis (except for the diameter of the right and left vertebral arteries and the linear velocity of blood flow in the vertebral artery on the right), weak and moderate negative correlations were found. A univariate analysis confirmed the existence of relationships between GFR, age, duration of CCI, and blood lipid parameters. Conclusions . The study revealed a statistical relationship between GFR and age, duration of CCI, lipid spectrum parameters, as well as with all 12 ultrasound parameters characterizing cerebral hemodynamics.