The synthetic approach of benzimidazole derivatives as anti-inflammatory agents

Anti-inflammatory drugs are a ubiquitous class of analgesics used by millions of people worldwide. Owing to the widespread and prolonged use of Anti-inflammatory drugs, chronic and acute toxicities have been reported in many human physiological systems. As a result, new anti-inflammatory drugs have been created recently, and several of them are in advanced phases of clinical studies. Chemists have been quite interested in heterocyclic compounds because of how similar they are to various biological precursors. One such heterocycle is benzimidazole and the most recent advancements of anti-inflammatory agents bearing benzimidazole have been emphasized in the current review. The review focuses on the synthetic route and the most promising benzimidazole derivative as an anti-inflammatory agent. The lead compound according to the literature will aid in the design and development of novel anti-inflammatory agents that target a diversity of factors contributing to inflammation.