用于癌细胞检测的高灵敏度生物传感器的光学模拟与优化

IF 0.7 4区 物理与天体物理 Q4 OPTICS Optica Applicata Pub Date : 2023-01-01 DOI:10.37190/oa230306
Abdelkarim El Mouncharih, Rabi Takassa, Omar Farkad, Abdelaziz Tchenka, El Alami Ibnouelghazi, Driss Abouelaoualim
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引用次数: 0

摘要

在这项工作中,我们利用二维时域有限差分方法,从理论上研究了一种基于硅棒的二维光子晶体生物传感器的光学特性,硅棒排列成正方形结构,在具有两个波导和一个纳米腔的空气底部。为此,将六个不同的细胞浸润到点缺陷中。这六种细胞分别是Jurkat、HeLa、PC-12、MDA-MB-231、MCF-7和基底细胞。因此,我们成功地通过透射光谱中的共振峰检测出这些细胞的癌症和良性病例。我们评估了灵敏度、质量因子、检测限和在不同值的感应区域半径的优值,以优化目的。我们在0.15 μm处观察到基底细胞的最大灵敏度为1350 nm/RIU。最后,所提出的生物传感器可以成为癌细胞检测模型中具有极高灵敏度的小型化结构。
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Optical simulations and optimization of highly sensitive biosensor for cancer cell detection
In this work, using the two-dimensional finite difference time domain method, we are theoretically studying the optical properties of a two-dimensional photonic crystal biosensor based on silicon rods arranged as a square structure in an air bottom with two waveguides and a nanocavity. For this purpose, six different cells are infiltrated into the point defect. These six cells are Jurkat, HeLa, PC-12, MDA-MB-231, MCF-7, and basal cells. As a result, we have successfully detected cancer and benign cases of these cells through resonance peaks in the transmission spectrum. We evaluated the sensitivity, quality factor, detection limit, and figure of merit at different values for sensing region radius for optimization purposes. We report that we observed the maximum sensitivity of 1350 nm/RIU at 0.15 μm for the basal cell. Finally, the proposed biosensor can be a miniaturized structure with extreme sensitivity in cancer cell detection models.
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来源期刊
Optica Applicata
Optica Applicata 物理-光学
CiteScore
1.00
自引率
16.70%
发文量
21
审稿时长
4 months
期刊介绍: Acoustooptics, atmospheric and ocean optics, atomic and molecular optics, coherence and statistical optics, biooptics, colorimetry, diffraction and gratings, ellipsometry and polarimetry, fiber optics and optical communication, Fourier optics, holography, integrated optics, lasers and their applications, light detectors, light and electron beams, light sources, liquid crystals, medical optics, metamaterials, microoptics, nonlinear optics, optical and electron microscopy, optical computing, optical design and fabrication, optical imaging, optical instrumentation, optical materials, optical measurements, optical modulation, optical properties of solids and thin films, optical sensing, optical systems and their elements, optical trapping, optometry, photoelasticity, photonic crystals, photonic crystal fibers, photonic devices, physical optics, quantum optics, slow and fast light, spectroscopy, storage and processing of optical information, ultrafast optics.
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