血小板活化因子乙酰水解酶(PAF-AH)活性对covid-19患者凝血功能的影响?

IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Clinical and Experimental Health Sciences Pub Date : 2023-09-11 DOI:10.33808/clinexphealthsci.1033882
Tülin BAYRAK, Gülsen ŞENER, Emel SAĞLAM GÖKMEN, Ahmet BAYRAK
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引用次数: 0

摘要

目的:异常的免疫炎症反应和细胞因子风暴在Covid-19死亡率上升方面发挥重要作用。我们的目的是研究血小板活化因子乙酰水解酶活性(PAF-AH)和血液学参数在确定疾病严重程度方面是否具有预后和预测价值。方法:共纳入84例新冠肺炎患者,其中52例在病房住院,32例在重症监护病房(ICU)住院,38例作为对照。& # x0D;结果:淋巴细胞和血清白蛋白水平显著降低(p <.001)、年龄、中性粒细胞、CRP、降钙素原、LDH、INR、d -二聚体水平均显著升高(p <.001)。ICU患者(p <.001)淋巴细胞、白蛋白值显著升高(p <.001)年龄、白细胞、中性粒细胞、CRP、INR、aPTT、d -二聚体水平与病区患者比较。与对照组相比,ICU患者PAF-AH活性显著升高(p <. 05)。ICU组PAF-AH与d -二聚体呈正相关。 结论:我们发现Covid-19患者PAF-AH活性升高。在凝血问题引起的心血管事件中发现PAF-AH活性是很重要的,这在未来可能会在这些患者身上看到。
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Platelet Activating Factor Acetylhydrolase (PAF-AH) activity : could it have a role on coagulation in covid-19 patients?
Objective: Abnormal immune inflammatory response and cytokine storm play an important role on the aspect of increasing mortality in Covid-19. We aimed to investigate whether the Platelet Activating Factor Acetylhydrolase activity (PAF-AH) and hematological parameters have prognostic and predictive value in determining the disease severity. Methods: A total of 84 Covid-19 patients, 52 of whom were hospitalized in the ward and 32 in the intensive care unit (ICU), and 38 control patients were included in this study. Results: Lymphocyte and serum albumin levels were significantly lower (p < .001) and age, neutrophils, CRP, procalcitonin, LDH, INR, D-dimer levels were significantly higher (p < .001) in Covid-19 patients compared to the control group. ICU patients had significantly lower (p < .001) lymphocyte, albumin values and significantly higher (p < .001) age, leukocyte, neutrophils, CRP, INR, aPTT, D-dimer levels compared to ward patients. PAF-AH activity was significantly increased in ICU patients compared to the control group (p < .05). A positive correlation was found between PAF-AH and D-Dimer in the ICU group. Conclusion: We found increased PAF-AH activity in patients with Covid-19. It’s important to spot the PAF-AH activity in cardiovascular events that develop due to coagulation problems, which are likely to be seen on these patients in the future.
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Clinical and Experimental Health Sciences
Clinical and Experimental Health Sciences MEDICINE, RESEARCH & EXPERIMENTAL-
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