Origanum Compactum Essential Oil Ameliorates Triton WR-1339-Induced Hyperlipidemia in Rats: Chemical Composition and Acute Toxicity

ABSTRACTThe impact of Origanum compactum essential oil (EO) at 80 mg kg−1 on Triton WR-1339-induced hyperlipidemia in rats was investigated.The EO’s phytochemical composition revealed the predominance of carvacrol (35.71%), p-cymene (13.74%), and carvacrol methyl ether (11.71%). Triton WR-1339 led to elevations in total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), as well asatherogenic indices encompassing the atherogenic coefficient (AC), Castelli’s risk index I (CRI-I), and Castelli’s risk index II (CRI-II). Conversely, pretreatment with O. Compactum EO for sevendays exerted a preventive effect against the increase of TC, TGs, LDL-C, VLDL-C, AC, CRI-I.KEYWORDS: Antihyperlipidemic effectmedicinal plantstoxicityLD50 Disclosure statementNo potential conflict of interest was reported by the author(s).Ethics ApprovalAll experiments were performed according to the local ethical committee, Faculty of Science and Techniques Errachidia, Morocco, number FSTE/2015.Abbreviations AC=Atherogenic coefficientCRI=Castelli’s risk indexEO=Essential oilHDL-C=High-density lipoprotein cholesterolHMG-CoA reductase=Hydroxymethyl-glutaryl coenzyme A reductaseLDL-C=Low-density lipoprotein cholesterolTC=Total cholesterolTGs=TriglyceridesVLDL-C=Very-low-density lipoprotein cholesterolAdditional informationFundingThis work was supported by the CNRST under grant N° PPR/2015/35.