毛绒绒甲醇提取物对高脂饮食致高脂血症大鼠降脂作用的测定

Rawal Pinkey, C Ramesh, BA Sowmya, CJ Ranjitha
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引用次数: 1

摘要

目的:研究毛参甲醇提取物对高脂饮食诱导的高脂血症大鼠的降血脂作用。方法:采用索氏提取器对毛参各部位的脱脂粉末状药物进行甲醇提取。本研究采用高脂饮食诱导的高脂血症大鼠模型,所有实验大鼠在整个研究期间均饲喂高脂饮食(HFD),并给予甲醇提取物21 d。给药1小时后,于第21天采集所有动物的血液,测定血清脂质(总胆固醇、甘油三酯、HDL、LDL和IDL)。取血、取肝后处死。结果:治疗组大鼠服用毛条提取物和标准药物阿托伐他汀后,血清胆固醇、血清甘油三酯、低密度脂蛋白显著降低,HDL显著升高,表明其具有减轻高脂饮食影响的能力。结论:毛绒绒甲醇提取物通过抑制肝脏胆固醇合成,对高脂饮食诱导的高脂血症大鼠具有明显的降血脂作用。
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Determination of lipid lowering properties of methanol extract of Tephrosia villosa against high fat diet induced hyperlipidemia in wistar rats
Objectives: The present study was performed to determine hypolipidemic potentials of methanol extract of Tephrosia villosa against high fat diet induced hyperlipidemia in wistar rats. Methods: Defatted powdered drug of ariel parts of Tephrosia villosa was subjected to methanol extraction using soxhlet extractor. The high fat diet induced hyperlipidemia in rat model was used for the present investigation in which all experimental rats were ingested with high fat diet (HFD) for entire period of study and were also administered with methanol extract for 21 days. Blood samples were collected from all the animals on day 21st after one hour of administration of the drugs and serum lipid profile (total cholesterol, triglycerides, HDL, LDL and IDL) was estimated. All animals were sacrificed after the blood sampling and liver samples were collected. Results: The rats of therapeutic groups ingested with extract of Tephrosia villosa and standard drug atorvastatin have shown significant reduction in serum cholesterol, serum triglycerides, LDL and increase in HDL indicating its ability to attenuate the effects of high fat diet. Conclusion: The methanol extract of Tephrosia villosa shown significant hypolipidemic effects against high fat diet induced hyperlipidemia wistar rats by inhibiting cholesterol synthesis in liver.
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