Green Extraction, Phytochemical Profiling, and Biological Evaluation of Dysphania ambrosioides : An In Silico and In Vitro Medicinal Investigation

ABSTRACTParasitic and microbial infections present substantial health risks, requiring effective treatments amidst growing antibiotic resistance. This study delves into Dysphania ambrosioides medicinal properties, utilizing hydro distillation and ultrasonic methods for extraction, followed by GC-MS analysis. Assessments revealed potent anti-diabetic effects in the methanol extract, significant antioxidant activity in the DCM extract and oil, and resistance against Escherichia coli. This research underscores the potential of local flora for novel treatments, particularly in underdeveloped regions. It emphasizes the value of plant screening in bioprospecting efforts, suggesting further investigations into specific bioactive compounds for pharmaceutical applications.KEYWORDS: Dysphania ambrosioidesTFCphytochemical screeningGC-MSantibacterialTPCantioxidant AcknowledgmentsFinancial assistance from the BfR (SFP 1322-807) is thankfully acknowledged.Disclosure StatementNo potential conflict of interest was reported by the author(s).Data Availability StatementData are available on request from the authors.Supplementary MaterialSupplemental data for this article can be accessed online at https://doi.org/10.1080/10496475.2023.2267467