抗菌肽:设计、化学合成、活性评价和应用

IF 0.7 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY international food research journal Pub Date : 2023-08-30 DOI:10.47836/ifrj.30.4.01
Hongyan Yang, Lan Wang, Heng Du, Dongxin Zhao, Chuang Liu, Kui Lu
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引用次数: 0

摘要

抗菌肽是存在于微生物、昆虫、两栖动物、植物和哺乳动物体内的活性短肽。一些天然存在的抗菌肽具有抗菌活性低、溶血能力强、对哺乳动物细胞有潜在毒性和对蛋白水解降解的高易感性等特点,限制了其实际应用。近年来,人们在设计和改造amp方面做出了许多努力,以改善其性能。目前的综述集中在定点突变,截断,杂交,封顶和amp的环化。综述了固相肽合成技术在抗菌肽合成中的应用,并对抗菌肽抗菌活性的评价方法进行了综述。对抗菌肽的深入研究有望在农业、畜牧业、食品工业和医药等领域发挥重要作用。
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Antimicrobial peptides: Design, chemical synthesis, activity evaluation, and application
Antimicrobial peptides (AMPs) are active short peptides that exist in microorganisms, insects, amphibians, plants, and mammals. Some naturally occurring AMPs have low antimicrobial activity, high haemolysis, potential toxicity toward mammalian cells, and high susceptibility to proteolytic degradation, which limit their practical application. In recent years, many efforts have been made to design and modify AMPs to improve their properties. The present review focuses on site-directed mutation, truncation, hybridisation, capping, and cyclisation of AMPs. The review further introduces the application of solid-phase peptide synthesis technology for AMPs, and summarises the methods for evaluating the antimicrobial activity of AMPs. The in-depth research on AMPs is expected to play an essential role in the fields of agriculture, animal husbandry, food industry, and medicine.
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来源期刊
international food research journal
international food research journal Agricultural and Biological Sciences-Food Science
CiteScore
1.40
自引率
0.00%
发文量
75
期刊介绍: The International Food Research Journal (IFRJ) publishes papers in English, six (6) issues a year with the coverage of: Food Science and Technology Nutrition and Dietetics Agriculture, multidisciplinary Chemistry, multidisciplinary The scope of the Journal includes: Food Science, Food Technology and Food Biotechnology Product Development and Sensory Evaluation Food Habits, Nutrition, and Health Food Safety and Quality Food Chemistry, Food Microbiology, Food Analysis and Testing Food Engineering Food Packaging Food Waste Management Food Entrepreneur Food Regulatory Post-Harvest Food Management Food Supply Chain Management Halal Food and Management
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