Run Tian , Tingting Yang , Chenghan Xiao , Fuping Li , Leyao Fu , Lu Zhang , Jiarui Cai , Sixuan Zeng , Junhao Liao , Guishuang Song , Chuan Yu , Ben Zhang , Zhenmi Liu
{"title":"夜间室外人造光与男性精子质量:一项中国回顾性队列研究。","authors":"Run Tian , Tingting Yang , Chenghan Xiao , Fuping Li , Leyao Fu , Lu Zhang , Jiarui Cai , Sixuan Zeng , Junhao Liao , Guishuang Song , Chuan Yu , Ben Zhang , Zhenmi Liu","doi":"10.1016/j.envpol.2023.122927","DOIUrl":null,"url":null,"abstract":"<div><p>Due to the worldwide increased rate of infertility among reproductive-age couples, there is a growing interest in the relationship between environmental stimuli and human sperm quality. While animal studies have demonstrated the detrimental effects of outdoor artificial light at night (ALAN) on sperm quality, investigations based on human data are lacking. Therefore, we conducted a retrospective cohort study involving 1991 sperm donor candidates and employed multivariate linear regression and restricted cubic spline models to quantify the association between outdoor ALAN and sperm quality. The aim was to determine whether there exists an association between exposure to outdoor ALAN and sperm quality. The study included 1991 sperm donor candidates with the following characteristics: mean [SD] age, 24.98 [4.78] years; mean [SD] BMI, 22.13 [2.60] kg/m<sup>2</sup>; mean [SD] sleep duration, 7.66 [1.07] hours/day. Outdoor ALAN exposure of study participants ranged from 0 to 100 nW/cm<sup>2</sup>/sr. Multiple regression analysis on chronic exposure (0–90 days before sperm donation) and human sperm quality revealed the following associations: for CASA primary motion parameters, every 100-unit (nW/cm<sup>2</sup>/sr) increase in chronic outdoor ALAN was associated with a change of −0.043 [95%CI: 0.073, −0.014] in Linearity (LIN), and −5.523 [95%CI: 9.100, −1.946] in Curvilinear velocity (VCL). For CASA secondary motion parameters, every 100-unit (nW/cm<sup>2</sup>/sr) increase in chronic outdoor ALAN was associated with a change of −3.873 [95%CI: 4.926, −2.748] in non-progressive motility rate (NP). Furthermore, the primary sperm quality parameter exhibited a decline of −4.740 [95%CI: 8.853, −0.628] in sperm motility rate per 100-unit (nW/cm<sup>2</sup>/sr) increase in chronic outdoor ALAN. Similar associations were also observed for acute exposure (0–9 days before sperm donation). This retrospective study suggests that poorer sperm quality is more prevalent among adult males residing in areas with higher levels of outdoor ALAN, with a particularly pronounced impact observed in males below the age of 25 years.</p></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":null,"pages":null},"PeriodicalIF":7.6000,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Outdoor artificial light at night and male sperm quality: A retrospective cohort study in China\",\"authors\":\"Run Tian , Tingting Yang , Chenghan Xiao , Fuping Li , Leyao Fu , Lu Zhang , Jiarui Cai , Sixuan Zeng , Junhao Liao , Guishuang Song , Chuan Yu , Ben Zhang , Zhenmi Liu\",\"doi\":\"10.1016/j.envpol.2023.122927\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Due to the worldwide increased rate of infertility among reproductive-age couples, there is a growing interest in the relationship between environmental stimuli and human sperm quality. While animal studies have demonstrated the detrimental effects of outdoor artificial light at night (ALAN) on sperm quality, investigations based on human data are lacking. Therefore, we conducted a retrospective cohort study involving 1991 sperm donor candidates and employed multivariate linear regression and restricted cubic spline models to quantify the association between outdoor ALAN and sperm quality. The aim was to determine whether there exists an association between exposure to outdoor ALAN and sperm quality. The study included 1991 sperm donor candidates with the following characteristics: mean [SD] age, 24.98 [4.78] years; mean [SD] BMI, 22.13 [2.60] kg/m<sup>2</sup>; mean [SD] sleep duration, 7.66 [1.07] hours/day. Outdoor ALAN exposure of study participants ranged from 0 to 100 nW/cm<sup>2</sup>/sr. Multiple regression analysis on chronic exposure (0–90 days before sperm donation) and human sperm quality revealed the following associations: for CASA primary motion parameters, every 100-unit (nW/cm<sup>2</sup>/sr) increase in chronic outdoor ALAN was associated with a change of −0.043 [95%CI: 0.073, −0.014] in Linearity (LIN), and −5.523 [95%CI: 9.100, −1.946] in Curvilinear velocity (VCL). For CASA secondary motion parameters, every 100-unit (nW/cm<sup>2</sup>/sr) increase in chronic outdoor ALAN was associated with a change of −3.873 [95%CI: 4.926, −2.748] in non-progressive motility rate (NP). Furthermore, the primary sperm quality parameter exhibited a decline of −4.740 [95%CI: 8.853, −0.628] in sperm motility rate per 100-unit (nW/cm<sup>2</sup>/sr) increase in chronic outdoor ALAN. Similar associations were also observed for acute exposure (0–9 days before sperm donation). This retrospective study suggests that poorer sperm quality is more prevalent among adult males residing in areas with higher levels of outdoor ALAN, with a particularly pronounced impact observed in males below the age of 25 years.</p></div>\",\"PeriodicalId\":311,\"journal\":{\"name\":\"Environmental Pollution\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.6000,\"publicationDate\":\"2023-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environmental Pollution\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0269749123019292\",\"RegionNum\":2,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Pollution","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0269749123019292","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Outdoor artificial light at night and male sperm quality: A retrospective cohort study in China
Due to the worldwide increased rate of infertility among reproductive-age couples, there is a growing interest in the relationship between environmental stimuli and human sperm quality. While animal studies have demonstrated the detrimental effects of outdoor artificial light at night (ALAN) on sperm quality, investigations based on human data are lacking. Therefore, we conducted a retrospective cohort study involving 1991 sperm donor candidates and employed multivariate linear regression and restricted cubic spline models to quantify the association between outdoor ALAN and sperm quality. The aim was to determine whether there exists an association between exposure to outdoor ALAN and sperm quality. The study included 1991 sperm donor candidates with the following characteristics: mean [SD] age, 24.98 [4.78] years; mean [SD] BMI, 22.13 [2.60] kg/m2; mean [SD] sleep duration, 7.66 [1.07] hours/day. Outdoor ALAN exposure of study participants ranged from 0 to 100 nW/cm2/sr. Multiple regression analysis on chronic exposure (0–90 days before sperm donation) and human sperm quality revealed the following associations: for CASA primary motion parameters, every 100-unit (nW/cm2/sr) increase in chronic outdoor ALAN was associated with a change of −0.043 [95%CI: 0.073, −0.014] in Linearity (LIN), and −5.523 [95%CI: 9.100, −1.946] in Curvilinear velocity (VCL). For CASA secondary motion parameters, every 100-unit (nW/cm2/sr) increase in chronic outdoor ALAN was associated with a change of −3.873 [95%CI: 4.926, −2.748] in non-progressive motility rate (NP). Furthermore, the primary sperm quality parameter exhibited a decline of −4.740 [95%CI: 8.853, −0.628] in sperm motility rate per 100-unit (nW/cm2/sr) increase in chronic outdoor ALAN. Similar associations were also observed for acute exposure (0–9 days before sperm donation). This retrospective study suggests that poorer sperm quality is more prevalent among adult males residing in areas with higher levels of outdoor ALAN, with a particularly pronounced impact observed in males below the age of 25 years.
期刊介绍：
Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health.
Subject areas include, but are not limited to:
• Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies;
• Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change;
• Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects;
• Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects;
• Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest;
• New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.
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