{"title":"硝苯地平和维拉帕米对半胱氨酸白三烯致绵羊子宫收缩的影响。","authors":"A Ledwozyw, A Kadziołka","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Both nifedipine and verapamil, the calcium channel blockers were tested to determine their anti-leukotriene properties in pig uterine strips. These drugs in concentrations ranging from 1.10(-7)M to 1.10(-5)M significantly attenuated the constrictor effects of cysteinyl leukotrienes in pig uterus. Thus, leukotrienes C4, D4 and E4 are dependent upon Ca2+ for their myotropic activity, an action non-competitively inhibited by the calcium channel blockers nifedipine and verapamil.</p>","PeriodicalId":20364,"journal":{"name":"Polskie archiwum weterynaryjne","volume":"29 1-2","pages":"189-200"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Effects of nifedipine and verapamil on cysteinyl leukotriene-induced contractions of the sheep uterus].\",\"authors\":\"A Ledwozyw, A Kadziołka\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Both nifedipine and verapamil, the calcium channel blockers were tested to determine their anti-leukotriene properties in pig uterine strips. These drugs in concentrations ranging from 1.10(-7)M to 1.10(-5)M significantly attenuated the constrictor effects of cysteinyl leukotrienes in pig uterus. Thus, leukotrienes C4, D4 and E4 are dependent upon Ca2+ for their myotropic activity, an action non-competitively inhibited by the calcium channel blockers nifedipine and verapamil.</p>\",\"PeriodicalId\":20364,\"journal\":{\"name\":\"Polskie archiwum weterynaryjne\",\"volume\":\"29 1-2\",\"pages\":\"189-200\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1989-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Polskie archiwum weterynaryjne\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polskie archiwum weterynaryjne","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Effects of nifedipine and verapamil on cysteinyl leukotriene-induced contractions of the sheep uterus].
Both nifedipine and verapamil, the calcium channel blockers were tested to determine their anti-leukotriene properties in pig uterine strips. These drugs in concentrations ranging from 1.10(-7)M to 1.10(-5)M significantly attenuated the constrictor effects of cysteinyl leukotrienes in pig uterus. Thus, leukotrienes C4, D4 and E4 are dependent upon Ca2+ for their myotropic activity, an action non-competitively inhibited by the calcium channel blockers nifedipine and verapamil.
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