心肌缺血再灌注损伤中细胞死亡的调控。

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-03-01 Epub Date: 2023-11-17 DOI:10.1016/j.tem.2023.10.010
Qi Xiang, Xin Yi, Xue-Hai Zhu, Xiang Wei, Ding-Sheng Jiang
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引用次数: 0

摘要

心肌缺血再灌注(I/R)损伤最常见于冠状动脉疾病,此时需及时再灌注挽救缺血心肌。心肌细胞死亡是心肌I/R损伤的重要组成部分,其机制以前被认为仅限于细胞凋亡和坏死。随着新型细胞死亡的发现,铁下垂、坏死下垂和焦下垂已被证明与心肌I/R有关。这些新形式的受调控细胞死亡通过影响活性氧(ROS)的产生、钙应激和炎症级联反应,导致心肌细胞损失和I/R损伤加剧,随后介导不良重塑、心功能障碍和心力衰竭。在此,我们回顾了铁下垂、坏死下垂和焦下垂在心肌I/R中的作用,并讨论了它们对病理的贡献。
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Regulated cell death in myocardial ischemia-reperfusion injury.

Myocardial ischemia-reperfusion (I/R) injury most commonly occurs in coronary artery disease when prompt reperfusion is used to salvage the ischemic myocardium. Cardiomyocyte death is a significant component of myocardial I/R injury and its mechanism was previously thought to be limited to apoptosis and necrosis. With the discovery of novel types of cell death, ferroptosis, necroptosis, and pyroptosis have been shown to be involved in myocardial I/R. These new forms of regulated cell death cause cardiomyocyte loss and exacerbate I/R injury by affecting reactive oxygen species (ROS) generation, calcium stress, and inflammatory cascades, subsequently mediating adverse remodeling, cardiac dysfunction, and heart failure. Herein, we review the roles of ferroptosis, necroptosis, and pyroptosis in myocardial I/R and discuss their contribution to pathology.

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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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